Transfusion and stem cell support in cancer treatment. David L,Wuest MD. Hematology Oncology Clinics of North America . 1996Wuest DL. Transfusion and stem cell support in cancer treatment. Hematol Oncol Clin North Am 1996; 10: 397–429
Stem cell-based therapies are emerging as a promising strategy to tackle cancer. Multiple stem cell types have been shown to exhibit inherent tropism towards tumours. Moreover, when engineered to express therapeutic agents, these pathotropic delivery vehicles can effectively target sites of malignancy....
This Opinion article considers the current status of stem cell-based treatments for cancer, such as the optimization of technologies to manipulate and deploy stem cells to target cancerous cells. It addresses safety concerns and discusses how the most pr
Nevertheless, pathways that regulate self-renewal and cell fate of normal stem cells, such as Wnt and hedgehog, are also involved in the regulation of cancer stem cells and tumor growth and progression, and may thus represent novel therapeutic targets in cancer treatment. In addition, the ...
The cancer stem cell (CSC) theory is gaining increasing attention from researchers and has become an important focus of cancer research. According to the theory, a minority population of cancer cells is capable of self-renewal and generation of differentiated progeny, termed cancer stem cells (CSCs...
Two recent discoveries by stem cell scientists at Cedars-Sinai may help make cancer treatment more efficient and shorten the time it takes for people to recover from radiation and chemotherapy.
Such insights lend direction to present and future attempts to treat cancer. The developing field of cancer stem cell biology is one of the most exciting of these advances.关键词: landscape ecology spatial scale temporal scale grain extent extrapolation models ...
Mutations in the well-known breast cancer susceptibility gene BRCA1 have a role in the propagation of aggressive stem cell-driven cancer. The findings, according to researchers at the University of Michigan, offer further evidence that breast cancer treatment strategies require a stronger focus on th...
Despite great progresses have been made in understanding the molecular basis of cancer, the progress in cancer detection and treatment, mortality is still high and there is not a cure despite great improvements have been made in therapies. Stem cell based regenerative therapies have raised hopes ...
Why are tumours heterogeneous, in terms of cell phenotype and proliferative potential, even in cases in which all cells are derived from a single clone? Ongoing mutagenesis can partially explain this heterogeneity, but it also seems that some tumours arise from small populations of 'cancer stem ce...