Steady stateDuring drug development, trough concentrations are usually monitored following repeated dosing to ensure that steady state has been achieved. Further utility of this information is explored in the estimation of intrasubject variability. Intrasubject variability is essential to the determination ...
1)steady-state concentration稳态浓度 1.A dosing regimen was given to obtain steady-state concentration after first bolus intravenous administration.对静注一级并行米氏消除动力学模型,导出了稳态浓度(最大值、平均值和最小值)精确值和近似值的计算公式,并讨论了平均稳态浓度与AUC/τ的关系,给出了一次给药即可...
During drug development, trough concentrations are usually monitored following repeated dosing to ensure that steady state has been achieved. Further utility of this information is explored in the estimation of intrasubject variability. Intrasubject variability is essential to the determination of sample si...
acurrent smokers achieved erlotinib steady-state trough plasma concentrations which were approximately 2-fold less than the former smokers or patients who had never smoked 当前吸烟者达到了比前吸烟者或患者是近似地2折叠较少未曾抽烟的erlotinib稳定低谷血浆集中 [translate] ...
However, before this time, constant peak and trough concentrations after intermittent doses, or constant concentrations during drug infusions, do not prove that a steady state has been achieved because drug may still be entering and leaving deep tissue compartments. During continuous infusion, the ...
Time to clinical steady state was measured from first dose until the serum IDeg trough concentration exceeded 90% of the final plateau level. The IDeg concentrations were log-transformed and analyzed using a mixed-effects model with time from first dose and dose level (where applicable) as fixed...
Plasma indinavir, SMZ, and TMP concentrations were determined after the last dose of each treatment period. Concomitant administration resulted in a 17% decrease in geometric mean trough plasma indinavir concentrations (p = 0.032), an 18% increase in geometric mean AUC0-12h and Cmax TMP values ...
On coadministration, AUCtau and Cmax of EVG and TPV and EVG and DRV were within prespecified no-effect boundaries versus treatment alone; trough concentrations were also not substantially altered. CONCLUSIONS: The PK of EVG and TPV or DRV were not altered after coadministration of EVG with TPV...
(AUC0-12), time to reach peak serum concentration (Tmax), peak serum concentration (Cmax), trough serum concentration (Cmin), average drug concentration (Cav), degree of fluctuation (DF), percentage of time serum drug concentrations lie within the therapeutic range (occupancy time) and time ...
A non-compartmental pharmacokinetic analysis of steady-state concentrations was performed using Phoenix WinNonlin version 8.1 (Pharsight, a Certara Company, Princeton, NJ, USA). Main pharmacokinetic parameters including area under the curve (AUC0–24h), maximum observed concentration (Cmax) and minimum...