The signal transducer and activator of transcription (STAT) proteins are among the most well studied of the latent cytoplasmic signal-dependent transcription-factor pathways. In addition to several roles in normal cell decisions, dysregulation of STAT function contributes to human disease, making the ...
donovani even in the absence of a strong Th1 response and develop minimal liver pathology. Studies in these mice have opened the possibility that resistance in STAT1−/− mice is due to a defect in the trafficking of monocytes and an inability of parasites to establish a suc...
Thus, the impaired responsiveness to IFN-γ due to STAT1 dysfunc- tion may provide a selective growth advantage to some malignant cells at an early stage of tumor development, a process known as cancer immuno-editing [26, 27]. Several reports showing that some spontaneous human tumors are ...
但JAK/sTATs信号传导通路在脑胶质 [15]GarciaR,BowmanTL,NiuG,eta1.Constitutiveactivationof 瘤的发生、发展中的具体作用机制尚待研究。 Stat3by theSrcand JAK tyrosinekinases participatesin growthregulationofhumanbraestacrcinoma cells[J].Onco— 总之,STATs信号转导通路与多种恶性肿瘤发 gene,2001,20(20):...
Indeed, the centralizers have become the financial equivalent of nymphomaniacs – kicking the capital centralization into liquidation of human and environmental capital to provide more cheap capital to the insiders. The solution is to address the fundamental corruption of the political mechanism. Over ...