Australian mortality statistics for rheumatoid arthritis 1950–81: analysis of death certificate data. Ann Rheum Dis. 1988; 47 (7):563–9. doi: 10.1136/ard.47.7.563. [ Cross Ref ]Wicks IP, Moore J, Fleming A (1988) Australian mortality statistics for rheumatoid arthritis 1950-81: analysis...
Notably, our results reveal three significant pathways and 275 genes in common in two datasets. The pathways we found are meaningful to uncover the disease mechanisms of rheumatoid arthritis, which implies that our statistics are a powerful tool in functional analysis of gene expression data....
We applied DISH to two previous GWAS datasets in Asian systemic lupus erythematosus and European rheumatoid arthritis populations. There was a high correlation between Z scores in the DISH and HLA genotype imputations, showing the same disease-susceptible and protective alleles. This study illustrated ...
Secondly, we found that estimates of R can be unreliable when there are strong effect loci within regions of long-range linkage disequilibrium (e.g., this was an issue for rheumatoid arthritis, where a single SNP within the major histocompatibility complex explains 2% of phenotypic variation). ...
Drug discovery (targeted, efficient trials)Rheumatoid arthritis101 Breast cancer with HER2102 Lung cancer with EML4–ALK fusion103 Disease diagnosis or risk predictionInfectious diseasesEbola104SNPs104,105GWAS105 Rare diseasesSevere intellectual disability106 ...
(Supplementary Data17) and are uniquely identified in cell type level TWAS but missed in whole blood. One gene identified for rheumatoid arthritis isC-C Motif Chemokine Receptor 1 (CCR1)(p-value = \(1.42\times {10}^{-11},{PIP}=1\)) in unstimulated NK cells. TheCCR1expression ...
infliximab for rheumatoid arthritis: emulating a randomized trial in observational data. Clin Pharmacol Ther. 2022;112(4):836-845. doi:10.1002/cpt.2673PubMedGoogle ScholarCrossref 35. Barda N, Dagan N, Ben-Shlomo Y, et al. Safety of the BNT162b2 mRNA COVID-19 vaccine in...
(Fig.5). We also note that ensemble PRS improved predictivefor every trait in the analysis with a median increase of 26.36% compared to PRS-CS-auto (Additional file 1: Fig. S37). Among 31 complex diseases and traits, we observed the highest prediction improvement for rheumatoid arthritis (...
One of AbbVie’s most well-known drugs is Humira, a medication used to treat autoimmune diseases such as rheumatoid arthritis and Crohn’s disease, which has been among the world’s top-selling pharmaceuticals for years. Abbvie Statistics ...
19. Approximately 21% of people who suffer from rheumatoid arthritis also suffer from fibromyalgia. (Medpage Today) Both arthritis and fibromyalgia are chronic pain conditions, yet they are not the same condition as many people may think.