Notably, our results reveal three significant pathways and 275 genes in common in two datasets. The pathways we found are meaningful to uncover the disease mechanisms of rheumatoid arthritis, which implies that our statistics are a powerful tool in functional analysis of gene expression data....
Rheumatoid arthritis (RA) and multiple sclerosis (MS) are chronic autoimmune diseases characterized by immune system dysregulation and inflammation. Investigating the genetic correlation between RA and MS can provide insights into shared genetic factors, potential mechanisms, and pathways un...
A history of thyroid problems such as goiter Previous thyroid surgery A family history of hypothyroidism Recent pregnancy or childbirth Use of nicotine products, such as cigarettes or vaping Having Turner syndrome,perniciouanemia,Sjögren’ssyndrome, type 1 diabetes, rheumatoid arthritis, or lupus Cau...
Among 31 complex diseases and traits, we observed the highest prediction improvement for rheumatoid arthritis (113.7%), Alzheimer’s disease (93.0%, 94.3%, and 109.5% on three datasets), and post-traumatic stress disorder (70.7%). Fig. 5 An ensemble PRS catalog for 31 complex traits. Y-...
Heart rate variability in patients with rheumatoid arthritis Heart rate variability (HRV) is a useful tool for the detection of sympathetic-parasympathetic balance in the autonomic nervous system. Autonomic nervous s... H Evrengül,D Dursunoglu,V Cobankara,... - 《Rheumatology International》 被引...
Secondly, we found that estimates of R can be unreliable when there are strong effect loci within regions of long-range linkage disequilibrium (e.g., this was an issue for rheumatoid arthritis, where a single SNP within the major histocompatibility complex explains 2% of phenotypic variation). ...
Drug discovery (targeted, efficient trials)Rheumatoid arthritis101 Breast cancer with HER2102 Lung cancer with EML4–ALK fusion103 Disease diagnosis or risk predictionInfectious diseasesEbola104SNPs104,105GWAS105 Rare diseasesSevere intellectual disability106 ...
Study of active controlled tocilizumab monotherapy for rheumatoid arthritis patients with an inadequate response to methotrexate (SATORI): significant redu... Determination of the clinical optimal dose of L-377 (methotrexate capsule) for the treatment of rheumatoid arthritis (in Japanese). Ensyo. 1996...
(CAD), inflammatory bowel disease (IBD), rheumatoid arthritis (RheuArth), multiple sclerosis (MultiScler), breast cancer, and prostate cancer. Three phenotypes were continuous: intelligence, height, and body mass index (BMI). Further information regarding phenotype definitions can be found in the ...
A more recent procedure for analysing group differences is the Wilcoxon-Mann-Whitney test. The associated graphs are based on the cumulative distribution function of the two treatment groups and the synthetic Receiver Operating Characteristic (ROC). Special differences, namely baseline dependencies, can ...