Statistical controversies in clinical research: long-term follow-up of clinical trials in cancerclinical trialsfollow-upLong-term follow-up is an important unmet need for the full analysis of new treatments for cancer. Earlier detection of cancer and more effective treatment have led to many more ...
control arm translates into a HR of 0.60 if median PFS is 6 months in the control arm; assuming no effect from subsequent treatments, the same hypothetical 4-month difference could carry over to OS and translate into an OS HR of 0.86, assuming a median OS of 24 months in the control ...
The BJC is owned by Cancer Research UK, a charity dedicated to understanding the causes, prevention and treatment of cancer and to making sure that the best new treatments reach patients in the clinic as quickly as possible. The journal reflects these aims. It was founded more than fifty year...
To address this question, according to Table 3, Chow and Shao proposed a test for testing the integrity of blinding.6 Without loss of generality, consider a parallel design com- paring a$2 treatments conducted at a single study site. Let Aij be the event in which a patient in the jth ...
The main classes of statistical treatments that have been used to determine if two groups of censored environmental data arise from the same distribution are substitution methods, maximum likelihood (MLE) techniques, and nonparametric methods. These treatments along with using all instrument-generated dat...
“solved” because someone else has worked on it is refusing to accept that there can be a solution or that some real progress has been made, because that would constrain the development of our research identity. I see this a lot in research related to human-computer interfaces, whether it...
The problem of type 1 error rates in clinical medicine research is discussed and a new measure of evaluating the incidences of type 1 error is presented. Three measures, including the experimentwise error rate, the error rate per experiment, and the percentage error rate are used to compute ...
In addition to synthesizing multiple factors, network meta-analysis has recently attracted much attention in evidence-based medicine because it simultaneously combines both direct and indirect evidence to compare multiple treatments and thus facilitates better decision making. First, we empirically compare ...
We elected not to include a randomized control arm, instead viewing these efficacy analyses as phase IIA trials: not intended to be definitive but rather to triage inefficacious treatments. Dose-toxicity-efficacy scenarios For each of the six combinations of dose-assignment mechanism and efficacy ...
such as those outside urban or suburban areas or without the financial resources to travel for treatment. Given its limited accessibility, there is a lack of standardization in precision medicine, which can make comparing patient treatments and outcomes problematic and determining the m...