For Patients with Colorectal Cancer, the Long-Term Use of Statins Is Associated with Better Clinical Outcomes To explore how the long-term use of statins influences the presentation and survival of patients with colorectal cancer (CRC), we conducted a retrospective... AA Siddiqui,H Nazario,A Mah...
Remarkably, our analysis revealed that approximately 44.3% of these top candidates could be considered for pharmaceutical repurposing. Moreover, integrating various databases, we achieved results absent in the literature to date, such as the explanation of the antitumor activity of hydrophobic statins ...
Most of these tweets were non–health related, dominated by comments about television commercials and the US President’s use reported in his publicly released physical examination results. Health-Related Mentions Person Posting For 1707 of 5201 tweets (32.8%), we could ascertain that the post was...
For statin gene signatures generated in HA1E cells, we performed pathway enrichment analysis on genes upregulated and downregulated in response to statin exposure, defined using z-score > 1 and z-score < −1 respectively. Although there is no consensus on the z-score threshold for ...
The results of 4S, CARE and LIPID indicate that statin therapy is highly beneficial in CAD secondary prevention for patients with both elevated and average LDL levels. Thus, most patients with CAD will benefit from statin therapy. Although CARE suggested that no further risk reduction occurs by ...
treatment.Results Only 24% of these patients reported currently taking a statin.The most important predictor of statin use among these patients was prior history of coronary heart disease.History of diabetes or hypertension,as well as treated in university affiliated hospitals is related to increased ...
However, their inhibitory action on HMG-CoA reductase also results in the depletion of i... H Gbelcová,M Leníček,J Zelenka,... - 《International Journal of Cancer》 被引量: 145发表: 2007年 In vivoevidence of duality effects for lovastatin in a nude mouse cancer model Statins, ...
Results in the Context of Previous Studies Although this is the first study, to our knowledge, to use quantitative methods to determine the TTB for statins, the concept of TTB for statins has long been recognized as potentially important, and our results are consistent with previous findings on...
Results Data from prospective observational studies generally reported a lower risk of fatal prostate cancer among statin users. There is some evidence for serum cholesterol-lowering as an indirect mechanism linking statins with advanced and fatal prostate cancer. Window-of-opportunity clinical trials show...
Results from the AFCAPS/TexCAPS (Air Force/Texas Coronary Atherosclerosis Prevention Study) (44) demonstrated just that with participants who had no clinical evidence of atherosclerotic cardiovascular disease. The subjects were randomized to receive either lovastatin or placebo and were followed for a ...