aStatins, originally developed to treat high cholesterol, are inhibitors of the enzyme 3-hydroxy-3-methylglutaryl, the rate-limiting enzyme of the mevalonate pathway. Statins,最初被开发对待高胆固醇,是酵素3羟3 methylglutaryl, mevalonate路的率限制的酵素的抗化剂。[translate] ...
[1] Goldberg AC, Leiter LA, Stroes ESG, et al. Effect of Bempedoic Acid vs Placebo Added to Maximally Tolerated Statins on Low-Density Lipoprotein Cholesterol in Patients at High Risk for Cardiovascular Disease: The CLEAR Wisdom Randomized Clinical Trial [published correction appears in JAMA. 2020...
The main treatment option for high cholesterol levels is a group of cholesterol-lowering drugs called statins. They act mainly on the liver enzymes responsible for cholesterol synthesis, reducing the production of cholesterol. This has been proven to be very effective in decreasing the morbidity and...
Statins, originally developed to treat high cholesterol, are inhibitors of the enzyme 3-hydroxy-3-methylglutaryl, the rate-limiting enzyme of the mevalonate pathway.5个回答 他汀类药物,最初开发用于治疗高胆固醇血症,是酶3 - 羟基-3 - 甲基戊二酰基,甲羟戊酸途径的限速酶的抑制剂。2013-05-23 12:21...
I have been told that I need to watch my diet and be more active, but if my cholesterol levels do not come down the doctor might prescribe me statins for cholesterol. That shocked me and made me realise that my current lifestyle is damaging my health. I am also worried about any side...
[21] Athyros VG,Tziomalos K,Karagiannis A,et al. Aggressive statin treatment, very low serum cholesterol levels and haemorrhagic stroke: is there an association? Curr Opin Cardiol, 2010;25(4):406-410. [22] De Caterina R, Scarano M,Marfisi R,et al. Cholesterol-lowering interventions and...
highlight advances in genetics, cell biology and clinical sciences investigating the relationship between cholesterol and Alzheimer's disease.Cholesterol, its catabolites and proteins that regulate cholesterol levels all modulate processing of amyloid precursor protein. Statins hold promise in therapy of ...
Not all cholesterol is bad. It's good, for instance, to have high levels of HDL ("good") cholesterol. HDL cholesterol prevents plaque buildup in the arteries by transporting the bad (LDL) cholesterol out of the blood to the liver. From there, your body gets rid of it. ...
The finaleffect is increased uptake of LDLs from the blood and reduced LDLcholesterol concentration. Additionally, statins increase levels ofhigh-density lipoproteins (HDLs) and decrease those of triglycer-ides [7]. All of these lipid-modifying effects are dose-dependent[2].Statins are hepato...
View PDF Download full issue Search ScienceDirect Indian Heart Journal Volume 67, Issue 5, September–October 2015, Pages 419-424Review ArticleLDL Cholesterol, Statins And PCSK 9 Inhibitors Author links open overlay panelSanjiv GuptaShow more Add to Mendeley ...