DEMENTIANITRIC oxideMEDICINE -- ResearchThe class of cholesterol lowering drugs known as statins, already widely used to prevent heart disease and stroke, may also reduce the risk of Alzheimer's disease and other dementias, according to two new studies.In the first study, which used data from ...
英文: Statins and Dementia中文: 他汀类药物与痴呆 英文: Statins and Blood-Brain Barrier中文: 他汀类药物与血脑屏障 英文: Statins is a -hydroxy- -mathylglutaryl-CoA(HMG-CoA)reductase inhibitor.中文: 他汀类药物是 -羟基- -甲基戊二酰辅酶A(HMG-CoA)还原酶抑制剂。
Statins are a class of drugs often prescribed by doctors to help lower cholesterol levels in the blood, which can help prevent heart attacks and strokes. Most people who take statin drugs tolerate them very well. But some people have side effects, which can include headache, having a hard ti...
( 2007 ) Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease . BMC Med 5 : 20 Previous studies have suggested that cardiovascular problems are major risk factors for the development of dementia, and that statins—drugs used to treat cardiovascular problems—might...
The article suggests that elderly patients with dementia and memory difficulties should be given drugs for cardiovascular disease to help slow their cognitive decline. During the Primary Care 2007 conference in Birmingham, England physician Patrick Brooke advised ...
Associations between statin use and dementiahave also been an ongoing concern. Thus far, evidence has not conclusively demonstrated whether the drugs are beneficial, harmful, or have no effect on dementia risk. A recentconference presentationat the Society of Nuclear Medicine and Molecular Imaging Annu...
Although they are well tolerated by most patients and have a safety profile, some patients have muscle level alterations. The biological effects associated with these drugs are known as pleiotropic; they are of such interest and diversity that explains, in part, some of the actions of statins, ...
Cholesterol-lowering drugs such as statins are widely used for the therapy of hypercholesterolemia. We analyzed the influence of lovastatin on RAGE shedding in mouse alveolar epithelial cells (MLE-12 cells) endogenously expressing RAGE and in HEK/RAGE cells. The deprivation of cellular cholesterol by...
Statins are anti-inflammatory and anti-oxidative drugs that are clinically well established for the prevention of cardiovascular diseases. They exhibit pleiotropic beneficial properties beyond cholesterol-lowering effects that most likely rest on the indirect inhibition of small Ras homologous (Rho) GTPase...
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