Because vascular and lipid-related mechanisms are thought to have a role in the pathogenesis of Alzheimer's disease and vascular dementia, we did an epidemiological study of the potential effect of HMGCoA (3 hydroxy-3methylglutaryl-coenzyme A) reductase inhibitors (statins) and other lipid-lowering...
Patients who had mild cognitive damage or normal cognition who used lipophilic statins were found to have more than twice the risk of developing dementia than to users of statins. 这说明,亲脂性他汀类药物可能会给患者带来更高的风险,因为它们通过血脑屏障的能力更强。 除此之外,其实他汀类药物还有别...
et al. Use of statins and the risk of dementia and mild cognitive impairment: A systematic review and meta-analysis. Sci. Rep. 8, 5804 (2018). Article ADS CAS Google Scholar Sinyavskaya, L. et al. Comparative effect of statins on the risk of incident Alzheimer disease. Neurology 90,...
Determinants of cardiovascular health, especially midlife dyslipidemia, are associated with an increased risk of dementia based on molecular and epidemiologic data. Given the potential role of dyslipidemia in the development of dementia, statins have been investigated as potential therapeutic options to ...
incidence of dementia and Parkinson's disease to varying extents Previous studies have suggested that cardio- vascular problems are major risk factors for the development of dementia, and that statins—drugs used to treat cardiovascular problems—might, therefore, reduce the inci- dence of dementia. ...
(Pharmacology) any of a class of drugs, including atorvastatin and simvastatin, that lower the levels of low-density lipoproteins in the blood by inhibiting the activity of an enzyme involved in the production of cholesterol in the liver
摘要: Objective Heart failure (HF) is associated with an increased risk of dementia, and studies show that dyslipidemia may be involved in the pathogenesis of dementia. However, it is unclea关键词: CEA functional parameters smoking cessation ...
2001/viewarticle/983476 Lipid Management: The Ins and Outs of Inclisiran 2001/viewarticle/999142 ACC 2024: Clinical Impact of New Data in Lipid Management 2001/viewarticle/lipids-and-dementia-complex-and-evolving-story-2024a10000th news Lipids and Dementia: A Complex and Evolving Story 2001...
Statins and the risk of dementia Dementia affects an estimated 10% of the population older than 65 years. Because vascular and lipid-related mechanisms are thought to have a role in the pathogenesis of Alzheimer's disease and vascular dementia, we did an epidemiological... HR Jick,GL Zornberg...
have a higher risk of dementia or Alzheimer’s disease if they took statins, and taking statins could actually help decrease the risk in some groups, such as people with heart failure. People with Alzheimer’s disease or mixed dementia might see an improvement in their dementia while on ...