The 4 reasons to test if the statins have a role in stroke prevention are: (i) a statistical link between elevated low density lipoprotein-cholesterol or decreased high density lipoprotein-cholesterol and ischaemic stroke; (ii) a redu...
The role of cholesterol in the pathogenesis of stroke, the role of the treatment of hypercholesterolemia in the prevention of stroke have been controversed. The explanation was based on the heterogenous characteristics of stroke, on the relationship between several risk factors, and on the role of...
(Pharmacology) any of a class of drugs, including atorvastatin and simvastatin, that lower the levels of low-density lipoproteins in the blood by inhibiting the activity of an enzyme involved in the production of cholesterol in the liver
The article presents information on the findings of a study according to which general practitioners (GPs) should consider twice before prescribing statins to patients who have suffered a stroke. The study was conducted by Dr Brandon Westover and colleagues, from Massachusetts General Hospital, in ...
Statins are a class of drugs often prescribed by doctors to help lower cholesterol levels in the blood. By lowering the levels, they help prevent heart attacks and strokes. Studies show thatstatinsmay reduce the risk ofheart attack,stroke, and even death from heart disease by about 25%. ...
Vascular risk factors, particularly hypertension, are strongly associated with the presence and progression of WMH [5]. Control of hypertension has been shown to delay WMH progression in stroke patients, especially among those with severe WMH at baseline [6]. Thus far, only a few studies have ...
Objective:To assess whether statin treatment before or after acute ischemic stroke (AIS) affects the risk of acute intracerebral hemorrhage (ICH), postacute ICH, and mortality within 90 days.Methods:Data were sought from the Virtual International Stroke Trials Archive, an international repository of ...
2.9% for myocardial infarction, and 7.1% vs. 5.2 for ischemic stroke. After adjustment, statin use was associated with a slightly decreased risk of VTE (adjusted HR: 0.95 [95% CI: 0.92-0.97]), driven by a reduced risk of unprovoked VTE (adjusted HR: 0.92 [95% CI: 0.89-0.95]). ...
A meta-analysis of trials showed that the greater the LDL cholesterol reduction, the greater the intima-media thickness and stroke risk reductions. Even if statins also have 'pleiotropic' effects, their main action seems to be through LDL reduction. The Heart Protection Study only included strokes...
Interventions in the management of serum lipids for preventing stroke recurrence especially with 3-hydroxy-3-methylglutaryl coenzyme a (HMG-CoA) reductase inhibitors (statins), to be of benefit in reducing CHD and stroke events in th... BN Manktelow,C Gillies,JF Potter - 《Cochrane Database of...