signaling pathways. statins activate the intrinsic apoptotic pathway by disrupting the prenylation of key regulatory proteins. therefore, the depletion of isoprenoids leads to the apoptosis of a variety of cancer cells [112,165]. simvastatin has also been shown to significantly inhibit the ...
The development of statins as “cholesterol-lowering” drugs began in the mid-1970s. Simvastatin, lovastatin, and pravastatin are all fungal-derived compounds with very similar structures, although the additional hydroxyl groups make pravastatin more hydrophilic than simvastatin or lovastatin. In contrast...
The last decade has seen an increase in the trend of HMG-CoA reductase inhibitor (statin) usage in the Western world, which does not come as a surprise noting that the latest American Heart Association heart and stroke statistics indicate an alarming prevalence of 80 million Americans (one in ...