In the process of reducing cholesterol to lower and lower levels we have managed to create varying degrees of mevalonate pathway blockade. It is this blockade of cholesterol, dolichol, CoQ10, selenoprotein, Rho and normal phosphorylation that has caused the flood of reports of adverse effects from...
Arthritis Research & Therapy Vol 5 No 4 Hall Viewpoint Put your heart into the joint benefits of statins! Frances C Hall ARC Rheumatology Lecturer, Addenbrooke's Hospital, Cambridge, UK Corresponding author: Frances C Hall (e-mail: fch22@medschl.cam.ac.uk) Received: 27 May 2003 Accepted:...
The development of statins as “cholesterol-lowering” drugs began in the mid-1970s. Simvastatin, lovastatin, and pravastatin are all fungal-derived compounds with very similar structures, although the additional hydroxyl groups make pravastatin more hydrophilic than simvastatin or lovastatin. In contrast...
The development of statins as “cholesterol-lowering” drugs began in the mid-1970s. Simvastatin, lovastatin, and pravastatin are all fungal-derived compounds with very similar structures, although the additional hydroxyl groups make pravastatin more hydrophilic than simvastatin or lovastatin. In contrast...
related mortality across the population. One would be wrong. Despitecontrolling cholesterol, Americans are as unhealthy as ever, living withincreasingly more chronic diseasesanddying at higher ratesthan ever before. Is it possible we were wrong about the relationship between cholesterol and heart ...