Preventive interventions should be offered only to patients whose life expectancy exceeds that of the intervention s time to benefit - if that time interval is known. In this metaanalysis, researchers determined the time to benefit after starting statins for preventing a first major adverse cardiovasc...
Acute coronary syndrome (ACS) is associated with a number of abnormalities in inflammation, endothelial function, and coagulation, all of which appear to be modulated by statins. We examined the time to benefit of different statin regimens in the Pravastatin or Atorvastatin Evaluation and Infection ...
Nonstatin drug and surgical therapies either have shown no significant benefit (estrogen, dextrothyroxine) or benefit after 1 to 5 years of therapy (intestinal bypass surgery, cholestyramine, clofibrate, niacin, and a combination of niacin and clofibrate). In conclusion, rapid time to benefit has...
Rationalizing prescribing for older patients with multimorbidity: considering time to benefit. Drugs Aging. 2013;30(9):655-666.PubMedGoogle ScholarCrossref 7. Russell BJ, Rowett D, Abernethy AP, Currow DC. Prescribing for comorbid disease in a palliative population: focus on the use of lipid...
Because trial data suggest that time to benefit for statins begins at 2 to 5 years,11 as a sensitivity analysis hazard ratios (HRs) were plotted at 2-year intervals after the index date to examine the association between statin use and mortality within a short time frame. In additional ...
Early time to benefit with intensive statin treatment: could it be the pleiotropic effects? Am J Cardiol, 96 (2005) 54f–60f Google Scholar [31] A.C. Sposito, S.N. Santos, E.C. de Faria, D.S. Abdalla, L.P. da Silva, A.A. Soares, et al. Timing and dose of statin therapy...
Second, we extrapolated statin benefit for patients receiving treatment over the course of their lifetime, which is a commonly used assumption in CVD modeling studies.11 We did, however, assume long-term compliance rates of 50% and reduced treatment effects accordingly. Third, we did not ...
Targeting persistence-enhancing interventions so that they have the most leverage and potential benefit will require knowledge of the time during therapy when discontinuation is most likely, and which patient subgroups are at highest risk. In addition, long-term persistence rates are necessary to ...
The relative effects of statin therapy on new-onset diabetes were similar among different types of participants and over time. Among participants with baseline diabetes, the RRs for worsening glycaemia were 1·10 (1·06–1·14) for low-intensity or moderate-intensity statin therapy and 1·24 ...
Naming functions this way also has a benefit that these names will be removed during minification (when building for production), which automatically makes your bundle smaller with no extra effort. Alternatively, you can use thenameFn()utility, which simply attachesdisplayNameproperty to the function...