Objectives This study evaluated the effect of statin therapy on mortality in individuals with significant coronary artery disease (CAD) stratified by age.Background Hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) significantly reduce morbidity and mortality in individuals with CAD. Unfortunately...
We agree with Roberts and colleagues that older patients at cardiovascular risk should not have statin therapy withheld.doi:10.1093/GERONA/63.2.213T. StrandbergK. PitkalaR. TilvisThe journals of gerontology. Series A, Biological sciences and medical sciencesStrandberg TE, Pitkala KH, Tilvis RS....
Statin therapy for Alzheimer’s disease: will it work? J Mol Neurosci. 2002;19(1-2):155-161.PubMedGoogle ScholarCrossref 7. Refolo LM, Pappolla MA, LaFrancois J, et al. A cholesterol-lowering drug reduces β-amyloid pathology in a transgenic mouse model of Alzheimer’s disease. ...
Advanced age (>80y) is one predisposing feature of statin-related myopathy.CK should not be routinely measured in individuals receiving statin therapy.Fluvastatin or rosuvastatin is associated with a lower risk of myopathy.Ezetimibe or colesevelam may be co-prescribed with statins.Consider alternative ...
The primary control group consisted of a random sample of nonusers of any LLDs (statins and nonstatins), using a propensity score based on sex, age group at the start date of statin therapy (≤40, 41-50, 51-60, 61-70, 71-80, and >80 years), duration of enrollment (1-<3, 3 ...
a variety of groups," said Duke biostatistician Michael Pencina, Ph.D., a senior author of the paper. "We were interested in how tailoring the guidelines could get beneficial treatment to those who really need it, and avoid over-treating patients whose risk may only be their sex and age....
Over 40% of deaths in China are attributed to cardiovascular conditions, and dyslipidemia is a key risk factor for atherosclerotic cardiovascular disease (ASCVD) [2, 3]. To mitigate the risk of major cardiovascular events, clinical guidelines worldwide recommend statin therapy for managing ...
PCV74 COST-EFFECTIVENESS OF STATIN THERAPY FOR THE PRIMARY PREVENTION OF CARDIOVASCULAR EVENTS PREDICTED BY THE REYNOLDS RISK SCORE IN HEALTHY MEN AND WOMEN AGED 40 TO 80 YEARS OF AGE主要由Wiegand P、Hay J编写,在2010年被收录,
32 Another population-based study in France of 120 173 patients 75 years and older demonstrated a significant association between higher risk of cardiovascular events and discontinuation of statin therapy over a 2-year period.33 As with available trial data, prior studies have been limited by ...
Statin Use According to clinical guidelines,26-28 statin therapy was recommended in addition to lifestyle therapy for patients with hypertension, type 2 diabetes, dyslipidemia, obesity, or metabolic syndrome. Linking to the EMRs from January 1, 2010, to December 31, 2020, we identified the use ...