Although statin therapy is well established to prevent atherosclerotic vascular disease (ASCVD) events in adults 40 to 75 years of age, it is less clear whether older adults benefit from statin therapy. The purpose of this review is to summarize the current evidence and guidelines on statin use...
Objectives This study evaluated the effect of statin therapy on mortality in individuals with significant coronary artery disease (CAD) stratified by age.Background Hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) significantly reduce morbidity and mortality in individuals with CAD. Unfortunately...
For individuals on statin therapy, the probability of diabetes is adjusted according to the relative risk of statin-induced diabetes [23]. Treatment strategies The treatment initiation strategy recommended by the guidelines is shown in electronic supplementary material Figure. S1. This study examines ...
Identifying which patients are at highest risk for not adhering to long-term statin therapy is an important step towards individualizing interventions to ... JE Lucas,TC Bazemore,C Alo,... - 《Plos One》 被引量: 0发表: 2017年 The 2018 AHA/ACC/Multisociety Cholesterol Guidelines: A Personal...
Several cardiologists have questioned whether assessment ofcoronary artery calcium(CAC) should be used to evaluate patients for statin therapy, as currently recommended in guidelines since the National Cholesterol Education Program (NCEP) Adult Treatment Panel III update was published in 2004.[1]Serum ...
There were no differences in harms of statin therapy based on within-study analyses stratified according to age (4 trials),39,40,43,44 sex (2 trials),43,45 or race and ethnicity (1 trial) (eTable 9 in the Supplement).46 In JUPITER, high-intensity statin therapy was associated with inc...
Statin Therapy in Young Adults Young adults below 35 years of age who do not have an exceedingly rare genetic disorder such as familial hypercholesterolemia are at very low short-term (5... MJ Pletcher,SB Hulley - 《Journal of the American College of Cardiology》 被引量: 35发表: 2010年 ...
15 Guideline-Defined Treatment Thresholds for Statin Therapy In the present study, we compared class I and strong recommendations for primary prevention with statins. In sensitivity analyses, we also included weaker class II recommendations. The 2021 European-ESC guidelines recommend age-specific ...
The greater age of the non-statin group may have caused aspirin to be underused due to intolerance and increased risk of bleeding. Furthermore, dual-antiplatelet therapy is not superior to aspirin alone in patients at high risk for atherothrombotic events26. Given the interventional strategy, the...
Rotter, MD; Philip Greenland, MD; Maryam Kavousi, MD, PhD JAMA Comment & Response Cost-effectiveness of Statin Use Guidelines Conrad B. Blum, MD; Neil J. Stone, MD JAMA Cardiology Key Points Question What is the cost-effectiveness of statin therapy guidelines with and without use of ...