Background:Statins are generally well tolerated, but some patients discontinue therapy secondary to adverse effects. Dosing a statin (rosuvastatin) every other day (EOD) may provide significant lipoprotein changes while avoiding common adverse effects in this statin-intolerant population. Objective:To dete...
Effectiveness and toler- ability of every-other-day rosuvastatin dosing in patients with prior statin intolerance. Ann Pharmacother. 2008;42(3):341-346.Backes JM, Venero CV, Gibson CA, et al. Effectiveness and tolerability of every-other-day rosuvastatin dosing in patients with prior statin ...
摘要: Every-other-day dosing, especially of statins with longer half-lives is shown to preserve lipid-lowering benefits.年份: 2013 收藏 引用 批量引用 报错 分享 全部来源 求助全文 Semantic Scholar 相似文献Alternate-Day Statin Therapy for the Treatment of Hyperlipidemia OBJECTIVE: To evaluate the ...
Dr. Weintraub:Correct. I will try every-other-day dosing of certain drugs. A newer statin,pitavastatin, is not metabolized significantly via the cytochrome system in the liver. It is glucuronidated instead, so this drug is associated with a lower incidence of myalgias. ...
Effectiveness and tolerability of every-other-day rosuvastatin dosing in patients with prior statin intolerance. Ann Pharmacother 2008;42:341-6 14. Athyros VG, Tziomalos K, Kakafika AI, et al. Effectiveness of ezetimibe alone or in combination with twice a week Atorvastatin (10 mg) for ...
every day, those with statin intolerance who were able to take rosuvastatin intermittently or fewer than five times per week and those who could not take rosuvastatin at all. The results revealed that for those with statin intolerance, “even with intermittent dosing, you get a nice reduction ...
Consequently, to control for confounding factors in the analyses, every participant abstained entirely from alcohol and smoking during the research. Additionally, after vigorous physical exertion, CK levels can rise 30 times above the normal upper limit within one day and slowly decrease over the ...
26 report that lipophilic statins have more potent anticancer effects than hydrophilic statins, and that both higher dosing and continual dosing (once every half-life) are required for statins to exert a significant antitumor effect. Thus, we replaced normal chow with EnsureR plus (a liquid human...
Until December 2020, the European Commission approved inclisiran (a small interfering RNA targeting hepatic PCSK9 synthesis) with an infrequent dosing for heterozygous familial hypercholesterolemia (starting with an initial dose, then administered again at 3 months and then every 6 months thereafter), ...
Best corrected VA acuity (EDTRS) and fundus photography were obtained every 6 months and at exit from the study. Duration of treatment was a minimum of 1 year. Physicians trained in internal medicine were involved in the design of the pilot study and in monitoring the patients during the ...