addition of extended-release niacin to statin therapy was demonstrated to increase HDL cholesterol level by 21% and slow the progression of atherosclerosis measured by change in carotid intima–media thickness compared with statin therapy alone in patients with known CHD and low HDL cholesterol levels...
Statin-related muscle side effects are a constant healthcare problem since patient compliance is dependent on side effects. Statins reduce plasma cholesterol levels and can prevent secondary cardiovascular diseases. Although statin-induced muscle damage
Higher cholesterol levels, not statin use, are associated with a lower risk of hepatocellular carcinoma Article Open access 20 December 2019 Statin use is associated with a reduced incidence of colorectal cancer expressing SMAD4 Article 26 October 2021 Statins and prostate cancer—hype or hope...
Because statin affects the production of cholesterol we also evaluated the influence of statin, on adrenal and testicular steroidogenesis and the morphology of the reproductive tract tissues in animals receiving statin for a period of 12 weeks post surgery. Simvastatin significantly increased fracture ...
Although the guidelines attempt to be more holistic in their approach to addressing cholesterol levels, the guideline-advocated risk calculator is heavily weighted for age, essentially relegating every man to statin therapy by age 65 and every woman by age 70, even in the face of otherwise exemp...
Cerivastatin sodium, a novel statin, is a synthetic, enantiomerically pure, pyridine derivative that effectively reduces serum cholesterol levels at microg... W Mück - 《Clinical Pharmacokinetics》 被引量: 205发表: 2000年 Effect of cerivastatin sodium, a new inhibitor of HMG‐CoA reductase, on...
Across all trials, mean LDL-C levels ranged from 108 to 191 mg/dL, HDL-C levels ranged from 36 to 62 mg/dL, and total cholesterol levels ranged from 195 to 271 mg/dL (to convert HDL-C and total cholesterol values to mmol/L, multiply by 0.0259). Two trials enrolled some patients ...
(≥200 mg/dL), and using glucose-lowering agents; they also had similar mean blood glucose levels and patient follow-up periods. During the follow-up period, the statin users decreased their mean LDL cholesterol by a mean (SD) of 25 (31.6) mg/dL compared with a 0.8 (23.7) mg/dL ...
and other adverse effects. Thus the adverse maternal effects result from exaggerated pharmacologic activity at the dose levels administered (i.e., inhibition of the enzyme HMG-CoA reductase, its immediate product mevalonic acid, and cholesterol biosynthesis). It is not known whether pregnancy enhances...
Statins have been reported to prevent the development of hepatocellular carcinoma (HCC). We examined whether statin therapy is associated with decreased HCC recurrence in patients who underwent liver transplantation for HCC. Three hundred forty-seven pat