it should have full participation of the people. It must ensure democracy in terms of both process and outcomes. It must encompass both procedural and substantive democracy, both direct and indirect democracy. It must ensure...
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol. Cell 38, 576–589 (2010). Article CAS PubMed PubMed Central Google Scholar Dobbyn, A. et al. Landscape of conditional eQTL in dorsolateral prefrontal ...
Soil surface erosion can shape the morphography of rivers and estuaries in the natural environment and induce high potential risks to structures in engineering. Numerical simulations based on continuum mechanics theory can provide reliable assessments of the evolution of surface erosion from the perspectiv...
Activated GPCRs can stabilize the G protein in the nucleotide-free (apo) state, thereby facilitating GTP-GDP exchange8,9,10. The G protein nucleotide exchange step is likely accomplished by opening the cleft between the two domains of a given Gα protein in conjunction with docking of the α...
Cell Biol. 18, 758–770 (2017). Article CAS Google Scholar Machiels, J. P. et al. Afatinib versus methotrexate as second-line treatment in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck progressing on or after platinum-based therapy (LUX-Head & Neck 1...
Since the discovery of the gene associated with cystic fibrosis (CF), there has been tremendous progress in the care of patients with this disease. New therapies have entered the market and are part of the standard treatment of patients with CF, and have
Cantwell, Rebecca
Factors that Determine Relative Construction Costs Real Estate Prices This almost goes without saying, but if you’re building new, the cost of real estate is going to be a huge factor. You can see themedian home prices in every state here. You can seerecent changes in housing costs by st...
making cell-state heterogeneity a challenge for therapeutic management of breast tumors. An additional challenge to therapeutic treatment is the inherent plasticity of tumor cell states20,21,22. Cytotoxic and targeted therapies have been shown to drive cells into drug tolerant persister (DTP) cell sta...
10.1038/ncomms11510 OPEN Engineering electrocatalytic activity in nanosized perovskite cobaltite through surface spin-state transition Shiming Zhou1, Xianbing Miao1, Xu Zhao1, Chao Ma1, Yuhao Qiu2, Zhenpeng Hu2,3, Jiyin Zhao1, Lei Shi1 & Jie Zeng1 The activity of electrocatalysts exhibits a...