As a first step towards inferring covariation of gene programs within locally interacting cell types, NiCo has implemented different versions of non-negative matrix factorization (NMF). For each cell type, NiCo infers latent factors by integrative NMF25,26to capture common variability in the spatial ...
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, n; M1, M2,…, Mn are the centroids of polygon 1, 2, …, n; and Q1i,Q2i,…,QLii are the vertices of polygon i, as shown in Fig. 24.5. The calculation process of the proposed state matrix method can be divided into the following seven steps. Sign in to download full-size ...
Continuous irradiation of ppR with green light (520 nm) resulted in the accumulation of late-active intermediates such as multiple M-intermediates (M1, M2, and M3) because of their long lifetimes as compared with the early photointermediates such as the K- and L-intermediates. Generally, the ...
However, the functional consequence of LEC priming of CD8+ T cells is unknown. Here, we show that while many proliferating LEC-educated T cells enter early apoptosis, the remainders comprise a long-lived memory subset, with transcriptional, metabolic, and phenotypic features of central memory and...
d1 −1 dN −1 ∑∑|y 〉 = M1[s1] MN[sN ]| s1 sN 〉, s1=0 sN =0 (10) wdihmeerenstihoenMbyi[sD] a=r me Daxi =DDi.i + 1 matrices with D1 =DN + 1 = 1. We denote the bond Direct tomography. This method proceeds by disentangling all ...
Pathologic accumulation of tau into paired helical filaments and subsequently NFTs initially provide distinct targets. However, intracellular NFTs can be varied in composition and form. Different isoforms of NFT tau are associated with different disease states, predominantly 3R tau in Pick’s disease, ...
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Generally, in the described system the state of complete synchronization of all pendula (see Movie M1) co-exists with the state of partial phase synchronization in which two pendula oscillate in antiphase and the third one is at rest (see Movie M2) and the smallest chimera state (see Movie ...
Channel openings occur in the form of bursts, which are grouped as rapid openings and closings of the channel. These bursts are separated by distinct periods of long channel closing (Sakmann et al., 1983). Binding of Gβγ stabilizes the channel in the bursting state. However, the bursting...