Cytochrome P450 1A1 (CYP1A1) is a hydroxylase mainly controlled by the inflammation-limiting aryl hydrocarbon receptor (AhR), which plays a critical role in mycoplasma infection, oxidative stress injury, and cancer. Arginase-1 (Arg-1) is a surrogate for polarized alternative macrophages and is ...
M2型巨噬细胞信号通路JAK1,STAT6和P-STAT6信号通路蛋白也呈现逐渐升高的趋势,iNOS的表达呈显著降低的趋势,Arg-1的表达量在6 h时较高(t=9.35,P<0.05).Real-time PCR检测TNF mRNA相对表达量逐渐降低,iNOS mRNA相对表达量在6 h时升高,之后降低;Arg-1 mRNA相对表达量的相对表达量逐渐升高,48 h时表达量升高...
The burst of intracellular calcium induced by either bradykinin (B2 agonist) or des-Arg10-Lys-bradykinin (B1 agonist) in gingival fibroblasts pretreated with IL-1尾 was impaired by IL-4. Similarly, the increased binding of B1 and B2 ligands induced by IL-1尾 was decreased by IL-4. In ...