Interleukin-2 (IL-2) induces DNA binding of STAT5, a member of the family of cytokine-regulated transcription factors termed 'signal transducers and activators of transcription'. IL-2-stimulated STAT5-DNA complexes include two tyrosine phosphoproteins which exhibit distinct mobilities in SDS-PAGE ...
结果经IL-2刺激后,处于M0的RAW 264.7细胞显著上调表达M1型标记分子,如IL-1β、IL-12、TNF-α和i NOS等;IL-2使巨噬细胞中M1型的比例由3.2%上升到24.6%,同时Jak3和Stat5分子的磷酸化水平显著提高。结论 IL-2具有促进巨噬细胞由M0向M1极化的作用,且该作用可能是通过Jak3-Stat5通路实现。 展开 ...
Western blot检测Jak3和Stat5活化水平.结果 经IL-2刺激后,处于M0的RAW 264.7细胞显著上调表达M1型标记分子,如IL-1β、IL-12、TNF-α和iNOS等;IL-2使巨噬细胞中M1型的比例由3.2%上升到24.6%,同时Jak3和Stat5分子的磷酸化水平显著提高.结论 IL-2具有促进巨噬细胞由M0向M1极化的作用,且该作用可能是通过Jak...
IL-2R信号通路中STAT5对转录因子Foxp3表达调控.pdf,中国免疫学会中医药免疫分会 Tab.1 effectsofDSSOil avoidancetestin of SD The bilateral passive intrahippocampalinjectionAB(1.42)in rats(x=LSD). Data WS with theDuncans wasusedto difference One-wayANOVA,an
Interleukin-2 (IL-2) induces DNA binding of STAT5, a member of the family of cytokine-regulated transcription factors termed 'signal transducers and activators of transcription'. IL-2-stimulated STAT5-DNA complexes include two tyrosine phosphoproteins which exhibit distinct mobilities in SDS-PAGE ...
目的探讨IL-21,IL-2,STAT3和STAT5在支气管哮喘儿童外周血单核细胞中的水平变化.方法哮喘患儿按照治疗前后分为急性发作组(n=32)和缓解组(n=26),随机选取同期30例健康儿童作为对照组;ELISA法检测血清IL-21和IL-2水平,Westernblotting法检测PBMC中p-STAT3,p—STAT5的蛋白表达,肺功能仪检测3组肺功能,并分析I...
An upregulation of TOX was observed in activated CD8 + T cells upon stimulation with IL-2. Although its role is T cell development is well studied, its role in cancers is less known. Various studies have shown the association between TOX subfamily of genes and cancer [3], [4]. Due to...
存在IL-6/STAT3信号通路激活,且Th17细胞的表达水平与IL-6,STAT3mRNA的表达水平均呈正相关,提示IL-6/STAT3信号通路激活参与了HSP发病,Th17细胞增殖,活化与IL-6/STAT3信号通路激活有关,而IL-2/STAT5信号通路活性下调,且Treg细胞的表达水平与IL-2,STAT5mRNA表达水平呈正相关,提示Treg细胞的表达下调与IL-2/STAT5...
IL-6 和 TGF-β的变化无显著性差异(均为P>0.05);Th17/Treg失衡与HBV-DNA水平呈正相关(P<0.05).3.慢性乙型肝炎患者与正常对照组相比,STAT3,STAT5蛋白的表达明显升高(均为P<0.001).在慢性乙型肝炎患者中,STAT3蛋白表达与IL-6,IL-17,Th17及Th17/Treg存在显著正相关性(均为P<0.05),与IL-2,TGF-β存在显著...
摘要 目的考察伏九贴敷药物(白芥子、甘遂、延胡索、细辛组成)通过IL-6/信号转导器和转录激活因子3(STAT3)、IL-2/信号转导器和转录激活因子5(STAT5)信号通路对哮喘大鼠CD4+T辅助细胞17(Th17)/CD4...展开更多 Objective This study aims to investigate the regulatory effects of Fujiu Patch(composed of Sina...