Stat dimers bind to interferon response element (IRE) and gamma interferon-activated sequence (GAS) DNA elements, resulting in the transcriptional regulation of downstream genes (1,2). The remarkable range and specificity of responses regulated by the Stats is determined in part by the tissue-...
The stimulation of the DeltaNp63 transcriptional activity by DeltaNp63alpha is abolished by Janus kinase 2 (JAK2)/STAT3 inhibitor AG490, dominant-negative STAT3, STAT3 small interfering RNA, and deletion of the STAT3-RE sequence from DeltaNp63 promoter. Taken together these observations clearly ...
STAT3 belongs to the family of STAT (signal transducers and activators of transcription) proteins which are phosphorylated by receptor associated kinases, translocate to the nucleus, and act as transcription factors in response to cytokines and growth factors. Coactivators such as CREB-binding protein ...
We found that the interaction between STAT3 and NORAD is mediated by a structured region in the 3’ domain of NORAD, downstream to the Alu element that is present only in hominoids. This led us to propose that the introduction of Alu changed the sequence and structure of the region ...
STAT3 belongs to the family of STAT (signal transducers and activators of transcription) proteins which are phosphorylated by receptor associated kinases, translocate to the nucleus, and act as transcription factors in response to cytokines and growth factors. Coactivators such as CREB-bindi...
We found that the interaction between STAT3 and NORAD is mediated by a structured region in the 3’ domain of NORAD, downstream to the Alu element that is present only in hominoids. This led us to propose that the introduction of Alu changed the sequence and structure of the region ...
Ray, S., Sherman, C.T., Lu, M. & Brasier, A.R. Angiotensinogen gene expression is dependent on signal transducer and activator of transcription 3-mediated p300/cAMP response element binding protein-binding protein coactivator recruitment and histone acetyltransferase activity.Mol. Endocrinol.16, 82...
Subsequently, STAT3 protein is phosphorylated by JAKs predominantly at the Y705 site, leading to the activation and dimerization of STAT3, which will rapidly enter the nucleus, specifically bind to the GAS sequence (TTC/ANNNG/TAA) or the interferon-stimulated response element sequence (AGTTTCNNTT...
Hydrogen peroxide (H2O2) is recognized to act as a signaling molecule. Peroxiredoxins (Prxs) have the ability to transfer H2O2-derived oxidizing equivalents to redox-regulated target proteins, thus facilitating the transmission of H2O2 signals. It has re
STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of STAT3 while the PIAS3 protein ...