Cytokines released by patients’ monocytes were quantified by Human ProcartaPlex™ Panel 1 multiplex. Samples with a purity >95% were assessed for their cytokine production. Briefly, 5 × 105CD14+cells were plated in 24-well plates for 12 h. At the end of the incubation, viability ...
Monocytes-SMC cross-talk induces an inflammatory phenotype of the resident SMC, but the involvement of STAT3 in phenotype switching is not known. Resistin is a cytokine found in human atheroma associated to monocytes/macrophages with role in inflammation associated with cardiovascular disease. The aim...
目前已发现多种信号因子可激活STAT3, 包括: (1)细胞因子(cytokine, CK): IL-6、IL-11、抑瘤素M(oncostatin M, OSM)、睫状神经营养因子(ciliary neurotrophic factor, CNTF)、瘦素(leptin)、白血病抑制因子(leukaemia inhibitory factor, LIF)等; (2)表皮生长因子(epidermal growth factor, EGF)、血小板源生长因...
As mentioned above, the activation of STAT3 signaling is commonly regulated by ligands which interact with cognate membrane receptors and thus activate STAT3; the membrane receptors and associated kinases including cytokine receptors, GPCRs, TLRs, RTKs, non-RTKs, serine/threonine kinases which directly...
Integration of ChIP-seq and RNA-seq analysis revealed that genes bound by pSTAT3-Y705 as well as those upregulated in CML-TKI LSCs were also found to be enriched in cytokine interaction and metabolism related signatures (Fig. 3B). Moreover, ingenuity pathway analysis also disclosed significant...
Myc, which reduces macrophage M2 polarization and IL-6/STAT3-signaling-mediated PDL1 expression [105]]. It has been shown that lncARSR functions as the signaling molecule that triggers M2 macrophages polarization by activating the STAT3 signaling pathway. It also alters the cytokine production and ...
1D). Our above results altogether indicate that THi differentiation is initially mediated by IL-6, which induces IL-23 responsiveness to enhance this differentiation STAT3 Hyperactivation Enhances THi Differentiation—STAT proteins are key factors mediating cytokine signals during TH1 and TH2 ...
Thus, overexpression of a p27 protein defective for CDK inhibition and bearing phosphomimetic mutations at T157 and T198 induces an invasive EMT phenotype in non-tumorigenic human mammary epithelial cells. The EMT program is initiated by EMT-inducing transcription factors including Snail, Slug, zinc-...
(ILEI), an oncogenic member of the FAM3 cytokine family, can mediate STAT3 signaling pathway to drive breast cancer stem cell formation and promote breast cancer progression [25]. In addition, TNFRSF1A, a gene encoding a transmembrane receptor for TNF-α, can be modulated by STAT3 and ...
(2011) WNT5A is induced by inflammatory mediators in bone marrow stromal cells and regulates cytokine and chemokine production. J Bone Miner Res. [96] Henrichsen E (1956) Alkaline phosphatase in osteoblasts and fibroblasts cultivated in vitro. Exp Cell Res 11: 115–127. [97] Rawadi G, Vays...