[18] Xiang Q, Chen W, Ren M, et al. Cabozantinib suppresses tumor growth and metastasis in hepatocellular carcinoma by a dual blockade of VEGFR2 and MET[J]. Clin Cancer Res, 2014, 20(11): 2959-2970. [19] Heine...
但不幸的是,靶向STAT3的小分子药物由于特异性较差等原因难以寻找【2】。 2019年11月11日,美国密歇根大学的王少萌教授课题组在Cancer Cell杂志上发表了题为A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo的论文,利用PROTAC(Proteolysis targeting chimera technology)...
Staining intensity and heterogeneity in each of the endometrial compartments (epithelium; stroma, including decidualized stromal cells; and vasculature) was assessed. The Mann-Whitney U test was used to analyze IL-11, pSTAT3, IL-11Ralpha and LIF immunostaining intensities in the samples. Results ...
Fig.4 Electrophoresis of p-JAK2 and p-STAT3 protein expression in LPS stimulated NCI-H292 cells 表5 清肺化痰汤含药血清对LPS刺激NCI-H292细胞中p-JAK2和p-STAT3信号通路蛋白表达的影响(`x±s,n=8) Table 5 Effect of Qingfei Huatan...
STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) in
英文名STAT3-IN-17 STAT3-IN-17生物活性 描述STAT3-IN-17是一种中度STAT3抑制剂(IC50=0.7μM;HEK蓝IL-6),在HeLa细胞中具有抗增殖活性。STAT3-IN-17具有良好的药代动力学特征。STAT3-IN-17还抑制丙酮酸铁氧还蛋白氧化还原酶(PFOR),并抑制幽门螺杆菌[1][2]。
Combined ChIP- and RNA-sequencing identifies IL11 as a direct transcriptional target of the heterodimer between MAFF and BACH1, which leads to activation of STAT3 signaling. Inhibition of IL11 results in similar levels of metastatic suppression as inhibition of MAFF. This study demonstrates the ...
经营模式: 代理商,生产商, 员工人数: 11-50 注册资金: 100万人民币 公司评价 暂时还没有评价我要评价 该公司其他产品 STAT3-IN-1 价格: ￥1540/瓶 产品详情: STAT3-IN-1 STAT3-IN-1 (compound 7d) 是的、选择性的、口服有效的STAT3 的抑制剂,其在HT29 和MDA-MB 231 细胞中的 ... 纯度:>99...
更新时间:2024-01-11 15:09:19 STAT3抑制剂VII结构式 常用名 STAT3抑制剂VII 英文名 STAT3-IN-8 CAS号 1041438-68-9 分子量 444.259 密度 1.6±0.1 g/cm3 沸点 519.8±50.0 °C at 760 mmHg 分子式 C19H7F7N2O3 熔点 N/A MSDS N/A 闪点 268.2±30.1 °C STAT3抑制剂VII用途 STAT3-IN-5是...
JEG-3 cells, like extra villous trophoblast (EVT), express mRNA transcripts encoding IL-11 and IL-11 receptor-伪 (IL-11R伪). Treatment of JEG-3 cells with IL-11 led to an increase in invasion across Matrigel extracellular matrix without an increase in proliferation. There was a dose-...