研究发现,在PTENpc−/−STAT3pc−/−小鼠的肿瘤细胞中,CREB和mTOR信号通路表达均上调,表明在前列腺癌的发展和转移中,STAT3对mTORC1和CREB信号起负反馈调节作用。在使用JAK/STAT抑制剂治疗LNCaP细胞异种移植模型后,p-CREB、CREB、...
体内异种移植模型显示STAT3抑制CREB和mTORC1通路并减弱雄激素反应，总之，STAT3作为mTORC1和CREB信号传导的调节因子，能够抑制PCa形成和发展。抗糖尿病药物二甲双胍已被证明具有潜在的抗肿瘤作用，研究人员利用二甲双胍治疗前列腺癌患者临床数据以及体内外研究实验表明了二甲双胍的STAT3 依赖性，STAT3敲低和缺失能够消除二甲...
接着,为确定参与STAT3依赖性转移进展调节的关键致癌或肿瘤抑制途径,研究人员基于FFPE激光捕获显微切割和Label free非标记定量蛋白组学技术构建了Ptenpc−/− Stat3pc−/−敲除小鼠差异蛋白网络,结果显示mTOR和CREB信号通路上调,TMA样本和数据分析确定了CREB信号传导在PCa患者中的临床相关性,表明STAT3低表达和CREB高表...
STAT3/LKB1通过调节mTORC1/CREB通路调控转移性前列腺癌 吉满生物 研究发现,STAT3和PTEN的缺失在前列腺癌中常见,且STAT3的激活可防止前列腺癌的发展和扩散。STAT3通过调控LKB1/AMPK信号抑制前列腺癌中mTORC1/CREB通路。二甲双胍的抗肿瘤作用依赖于STAT3,而高CREB水平与前列腺癌患者的肿瘤复发和转移相关。 甲状腺右叶低回声...
Coactivators such as CREB-binding protein are required for the transcriptional activation by STAT3. STAT3 can also be activated by Interferon-alpha, Interferon-gamma, EGF, PDGF and IL6. Phosphorylation on tyrosine 705 by JAK1 and JAK2 is essential for STAT3 dimer formation, nuclear translocation, ...
这些蛋白质的大激活,在特定的酪氨酸和丝氨酸残基磷酸化可能是STAT1α,3,4,和5。对统计各个家庭成员的具体功能了解甚少。它被证明是由IFN-α活性但不IFN-β。与STAT3的转录因子c-Jun和环腺苷酸反应增强子结合蛋白(CREB)。STAT3基因的小鼠在敲的缺失是致命的在早期胚胎阶...
EDI3 was found to be highly expressed in HER2-positive breast cancer cells, and it's overexpression has been associated with PI3K/Akt/mTOR and GSK3β downstream pathways, as well as transcription factors (HIF1α, CREB, and STAT3) [101]. TNF-α with IFN-γ increases STAT1 phosphorylation ...
the STAT3 gene is located on the q arm of chromosome 17. STAT3 has been shown to be activated by IFN-alpha but not IFN-beta. The transcription factors associated with STAT3 are c-Jun and cyclic AMP-responsive enhancer binding protein (CREB). STAT3 mediates the expression of a variety of ...
the STAT3 gene is located on the q arm of chromosome 17. STAT3 has been shown to be activated by IFN-alpha but not IFN-beta. The transcription factors associated with STAT3 are c-Jun and cyclic AMP-responsive enhancer binding protein (CREB). STAT3 mediates the expression of a variety of ...
p300/CREB-binding protein PTPs: Protein tyrosine phosphatases HNSCC: Head and neck squamous cell carcinoma TME: Tumor microenvironment DC: Dendritic cell MDSC: Myeloid-derived suppressor cell TAM: Tumor-associated macrophages cell TAN: Tumor-associated neutrophils cell T cell: T lymphocyte...