(2002) Roles of Stat1, Stat2, and interferon regulatory factor-9 (IRF-9) in interferon tau regulation of IRF-1. Biol. Reprod., 66, 393-400.MD Stewart,Y Choi,GA Johnson,LY Yu-Lee,FW Bazer,TE Spencer.Roles of Stat1, Stat2, and interferon regulatory factor-9 (IRF-9) in interferon ...
干扰素-I的所有成员都结合一个称为IFNAR的受体,该受体触发JAK激酶JAK1和Tyk2的激活,该激酶介导信号转导和转录激活因子(STAT)家族的两个成员STAT1和STAT2的酪氨酸磷酸化。 活化的STAT1和STAT2,连同干扰素调节因子(IRF)9,形成异三聚体复合物ISGF3,与数百个干扰素刺激基因启动子中干扰素刺激的反应元件结合。当IFN-III...
Mammalian IRF9 and STAT2, together with STAT1, form the ISGF3 transcription factor complex, which is critical for type I interferon (IFN)-induced signaling, while IFNγ stimulation is mediated by homodimeric STAT1 protein. Teleost fish are known to possess most JAK and STAT family members, how...
此外,在STAT3信号激活后还能够抑制STAT1、IRF7、IRF9基因的表达,从而抑制Ⅰ型IFN信号,最终也促进免疫抑制性TME形成。 STAT5 在乳腺癌和前列腺癌中,STAT5与Foxp3结合,能够维持其过表达的同时促进Treg细胞发育。 IL-8通过激活过表达的STAT5与乳腺癌细胞存活、化疗耐药以及转移有关。 与STAT3一样,过度激活的STAT5也...
干扰素调节因子9(IRF9)在人和哺乳动物的JAK-STAT信号传导中起着至关重要的作用,但是硬骨鱼中IRF9和STAT1之间的关系仍然未知。先前的研究阐明了青鱼的两种STAT1亚型(bcSTAT1a和bcSTAT1b)在草鱼呼肠孤病毒(GCRV)引发的先天免疫激活过程中起...
I 型干扰素(IFN)作为主要的免疫反应调节因子,包含多种亚型,通过与受体 IFNAR1/IFNAR2 结合,激活信号转导及转录激活因子 1(STAT1)和 STAT2,进而与干扰素调节因子 9(IRF9)相互作用,激活干扰素刺激基因(ISGs)的转录,在肿瘤发展过程中,IFN 的旁分泌和自分泌信号均发挥着重要作用 。
TLRs可以根据它们在细胞表面的定位进行分类,如位于质膜上的TLR1、2、4、5和6,识别检测到TLR3、7、8和9等核酸的微生物细胞表面分子或内体。TLRs的这种空间调控对下游信号激活和最终不同的下游基因表达至关重要。表面TLRs激活NF-κB信号和炎症反应,而内体TLRs激活IRFs和I型干扰素反应。
As a component of ISGF3 it is clear that STAT2 plays an essential role in the transcriptional responses to IFN-I with a strong dependence on STAT1. Previously, we showed that STAT2 also forms homodimers that interact with IRF9 (STAT2-IRF9) to activate transcription of ISRE containing ...
STAT2, the amount of the transcriptionally active U-STAT2-IRF9 dimer will be low, reducing the expression of proteins driven by this complex. These proteins mediate significant antiviral activity23as well as resistance to DNA damage in cancer cells.24,25Our study of the U-STAT1-U-STAT2 ...
STAT1、STAT2、IRF7 及CD16 基因缺陷患儿易出现严重的致死性的病毒感染,RORC、IL17RA、IL17RC、IL17F、ACT1、CARD9、IL12Rβ1 基因缺陷及STAT1 功能获得性突变者易出现难治性慢性皮肤黏膜念珠菌病。 治疗 急性感染期治疗原则包括: (1)早期进行规范的...