Immune cells need to sustain a state of constant alertness over a lifetime. Yet, little is known about the regulatory processes that control the fluent and fragile balance that is called homeostasis. Here we demonstrate that JAK-STAT signaling, beyond it
Docetaxel resistance represents a significant obstacle in the treatment of prostate cancer. The intricate interplay between cytokine signalling pathways and transcriptional control mechanisms in cancer cells contributes to chemotherapeutic resistance, ye
1.A fluidic testing system, comprising:a plurality of test chambers, each characterized by a length and a hydraulic diameter, wherein each of the plurality of test chambers has only one opening disposed along the length of the corresponding test chamber;a first inlet channel configured to flow ...
The DESIGNWIDTH= and DESIGNHEIGHT= options in the PATHDIAGRAM statement enable you to change the default design dimensions of path diagrams. You can accommodate more nodes (variables) in the path diagram by setting a larger design dimension. The SCALE= option in the PATHDIAGRAM statement adjusts ...
It is a model-based solution, and the additional parameters don't add that much additional complexity to the analysis; they are simply sampled sequentially in the MCMC simulation. This approach does take into account the uncertainty about the missing values so you can estimate the posterior ...
Den Toonder: “If you can test the drugs directly on a realistic human organ-on-chip model, incorporating the complexity of the body right away, then you can eliminate harmful or ineffective drugs much earlier in the process, thereby saving a lot of money.” ...
Reduced Cytokine Responses Are Correlated with Increased Baseline Levels of pSTAT and Elevation in Memory Cell Populations Given the systemic nature of this phenotype (Figure 1C), and the complexity of individual responses profiles (Figure 1B; individuals differed on the identity of assays in which...