Of all S. aureus strains isolated from lesional skin, up to 65% have been shown to produce exotoxins with superantigenic properties. Patients colonized with S. aureus have been treated with antibiotics in several open and double-blind placebo-controlled studies, with conflicting results. These ...
By quantifying growth inhibition, early killing and longer-term population clearance by all pairs of 14 antibiotics, we find that clearance interactions are qualitatively different, often showing reciprocal suppression whereby the efficacy of the drug mixture is weaker than any of the individual drugs ...
Staphylococcus aureusis a major cause of severe pulmonary infections. The evolution of multi-drug resistant strains limits antibiotic treatment options. To date, all candidate vaccines tested have failed, highlighting the need for an increased understanding of the immunological requirements for effectiveS....
Community-associated, methicillin-susceptible, and methicillin-resistant Staphylococcus aureus bone and joint infections in children: experience from India. Previously, the treatment of Staphylococcus aureus infections was less complex, as most of those isolated were susceptible to 尾-lactam antibiotics. In...
METHICILLIN-resistant staphylococcus aureusANTIBIOTICSANGIOTENSIN converting enzymeCAPTOPRILObjective: Captopril is a long-acting human angiotensin-converting enzyme (ACE) inhibitor that has been used to treat hypertension and heart failure for many years. In this study, it was aimed to determ...
aureus. Antibiotics indicated for severe/rapidly progressive infections, signs and symptoms of systemic illness, diabetes or other significant immunosuppression, advanced age, location of abscess in an area where complete drainage is difficult, lack of response to initial I&D (also assess for the need...
The treatment of S. aureus biofilms is hampered by the ability of the biofilm structure to shield bacteria from antibiotics as well as the host’s immune system. Therefore, new preventive and/or therapeutic interventions, including the use of antibody-based approaches, are urgently required. In ...
Because bacteria can be resistant to certain antibiotics, treatment consists primarily of intensive support therapy. Most patients recover in 7 to 10 days with proper treatment. With treatment, the mortality rate for staphylococcal toxic shock syndrome is about 3 percent. Streptococcal infections, by ...
Beta-lactam antibiotics targeting PBP1 selectively enhance daptomycin activity against methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 57, 5005–5012 (2013). 21 Leski, T. A. & Tomasz, A. Role of penicillin-binding protein 2 (PBP2) in the antibiotic susceptibility and ...
The Journal of Antibiotics(2020) Propyl-5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carbodithioate (HMPC): a new bacteriostatic agent against methicillin—resistant Staphylococcus aureus Tatiana Johnston Daria Van Tyne Eleftherios Mylonakis Scientific Reports(2018) ...