From early observations of tumor spread in the 19th century, such as Stephen Paget’s seminal “seed and soil” hypothesis, to today’s utilization of advanced imaging modalities and single-cell sequencing technologies, each milestone reflects our progressing understanding of the metastatic process. Cl...
The project leader orchestrates the activities of cross-functional participants representing development, procurement, production, and service, each of which has clear responsibilities at a given decision gate. Preparation for meetings is thorough and guided by standard templates, ...
stage-gate+1-905-304-8797 EnrollToday! “Developingandlaunchingnew productsisoneofthemost complexinitiativesanorgani- zationcanundertake.Ahigh quality,disciplinedStage-Gate Processisproventoimprove newproductsuccessrates.” DR.ROBERTCOOPER Best-sellingauthorand ...
1.组织过程资产Organizational process assets 2.项目范围说明书Project scope statement 3.项目范围管理计划Project scope management plan 4.批准的变更申请 Approved change requests 1.工作分解结构模板 Work breakdown structure templates 2.分解Decomposition 1.项目范围说明书(更新)Project scope statement(updates)_ 2...
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(Fig.6e) in our SCA as an E–M coupling sector, we cannot exclude the possibility that sector 2 also includes residues important for VSD activation or gate opening. However, sector 2’s spatial pattern includes abundant residues within the S4-S5 linker which strongly suggests sector 2 ...
are found to lead to either stable or metastable interactions with the actin filament. Myosin's motor core transitions and ATP hydrolysis product release from the active site are correlated with the closure of the actin-binding cleft. Concerning the pre-powerstroke state, a gate is proposed to ...