Stage 4A is where the cancer has spread within the lungs or to one area outside the lungs.Stage 4B is where the cancer has spread to several places in one or more organs that aren’t close to the lungs, such as the brain, liver, or bones.Small cell lung cancer (SCLC) Small cell ...
Limitations of Positron Emission Tomography: Exogenous Lipoid Pneumonia Mistaken for Stage IV Non-small Cell Lung CancerINTRODUCTION: Exogenous lipoid pneumonia (ELP) is caused by the inhalation of animal fats, vegetable or mineral oil. It is commonly seen in patients at high risk for aspiration ...
Non-negative matrix factorization (NMF) was performed to explore the heterogeneous molecular clusters based on the identified “cancer” cells (Fig. 4A). The results showed that early-stage cell characteristic genes were involved in the biological processes related to cell adhesion. Furthermore, the...
EGFRandKRASare two frequently mutated driver genes of LUAD. Early-stageEGFR-mutated non-small-cell lung cancer (NSCLC) cases usually have a better prognosis than wild-type orKRAS-mutated cases, even without tyrosine-kinase inhibitor (TKI) application15,16,17. Additionally,EGFRmutation is considere...
et al. Critical limitations of prognostic signatures based on risk scores summarized from gene expression levels: a case study for resected stage I non-small-cell lung cancer. Brief. Bioinform. 17, 233–242 (2016). Article Google Scholar Xu, H., Guo, X., Sun, Q., Zhang, M., Qi, ...
Small-Cell Lung Cancer Small-cell lung cancer (SCLC) is the most aggressive type of lung cancer, characterized by a rapid doubling time.1 This form of lung cancer is most frequently diagnosed in patients who have a history of heavy smoking.2 SCLC accounts for about 13% to 15% of all ne...
Disease ontology enrichment analysis confirmed that MMR genes were significantly enriched in cancer, especially in non-small cell lung cancer (Fig. 2E). To investigated whether MMR activity was dynamic in metastasis population, we further quantified MMR scores in scRNA-seq level using AUCell, UCell,...
Purpose: To describe the outcome of treating early-stage non-small-cell lung cancer (NSCLC) with an accelerated hypofractionated course of radiotherapy. Methods and Materials: A policy of treating early-stage NSCLC with a dose of 48 Gy in 12 once-daily fractions without elective irradiation of ...
Consistent with these observations, repression of Bmi-1 in highly metastatic breast cancer cells markedly reduces cell motility and invasion, as well as tumorigenesis and lung metastases in nude mice. In addition, repression of Bmi-1 reverses the expression of EMT markers and inhibits the Akt/GSK...
The aim of this study was to evaluate the potential impact of tumor size on the long-term outcome of colon cancer (CC) patients after curative surgery. A total of 782 curatively resected T4a stage CC patients without distant metastasis were enrolled. Pat