Metabolic acidosis in stage 5 CKD is high anion gap metabolic acidosis but with the anion gap generally not higher than 20 mEq/L. In CKD, the kidneys cannot produce enough ammonia in the proximal tubules to excrete endogenous acid into the urine in the form of ammonium. In stage 5 CKD, ...
The most frequent AEs in stage 3b–5 and stage 1–3a CKD patients, respectively, were constipation (7.8% and 2.8%) and diarrhoea (4.0% and 1.9%); all cases were mild or moderate in severity. AEs leading to patiromer discontinuation occurred in 5.7% and 2.4% of stage 3b–5 CKD and ...
Age ≥65 years, being female, stage 3A CKD, and the absence of nephrology visit and comorbidities (diabetes, established cardiovascular disease, heart failure, hypertension, or chronic nephritic syndrome) were associated with undiagnosed CKD (P < 0.001). The results also demonstrated an improvement...
In this study, we used the CKD Health Policy Model, a microsimulation model of CKD progression, to examine the cost-effectiveness of identifying persons for early-stage CKD screening (i.e., screening for moderate albuminuria) using two published CKD risk scores: one published by Bang et al. ...
Most patients experienced anadverse event(80%), the majority of which were mild or moderate in severity (Table 3). The most common adverse events (reported for ≥10% of patients) wereheadache(17%), fatigue (14%), nausea (14%), vomiting (14%), and insomnia (10%). Serious adverse eve...
Decedents with ESRD and cancer had similarly high rates of moderate or severe pain (53.7% vs. 57.8%; P = 0.34) and all other symptoms. Conclusion Older adults dying of ESRD had lower rates of advance care planning and higher treatment intensity near the end of life than similar patients ...
This study analyzed the relationships between UA levels and biomarkers of mineral bone metabolism and inflammation in patients with CKD in stages 3a–5 without dialysis requirements. The prevalence of hyperuricemia was rather high in CKD patients, reaching >50% of patients with this alteration, wherea...
This study analyzed the relationships between UA levels and biomarkers of mineral bone metabolism and inflammation in patients with CKD in stages 3a–5 without dialysis requirements. The prevalence of hyperuricemia was rather high in CKD patients, reaching >50% of patients with this alteration, wherea...
Regarding interacting medications, 50 unique drug combinations were detected that could be related with clinical significant DDIs, with 8% of them considered serious, 41% as needing close monitoring and the remaining 41% of moderate–minor clinical significance (Figure 3, Table 4). The underlying ...
Methods: This prospective cohort analysis followed patients, who were part of a multidisciplinary CKD care program, for 10 years. We aimed to determine the impact of multimorbidity on renal outcomes. Results: Overall, 1463 patients with stage 3–5 CKD were enrolled and stratified by the number ...