In many studies, it has been reported that Ki67 expression predicts poor prognosis in solid tumours like breast cancer, cervical cancer, prostate cancer, glioma and hepatocellular carcinoma.8 Proliferative activity of tumour cells can be determined by this marker. Ki67 was found to correlate with ...
In contrast, TP63, another cell-cycle-associated protein, similarly overexpressed in NE-low tumors, was reported to be a tumor suppressor associated with a better prognosis in lung cancer [74]. According to a recent study, MYC can act as a master regulator for NE-differentiation and can ...