After 8 weeks on this diet, mice were treated with CCX872 (ChemoCentryx, Mountain View, CA, USA) 30 mg/kg once daily or vehicle, both administered subcutaneously. Liver injury was assessed with serum alanine aminotransferase concentration, liver triglyceride content, and flow cytometry of ...
Patients with anal trauma, inflammatory bowel disease, malignant tumours, HIV, tuberculosis, actinomycotic infection and other perineal complications. (2) Special patients who are pregnant and lactating or patients with respiratory, digestive, circulation, blood system disorders, liver and kidney dysfunct...
Effects of time-restricted feeding (16/8) combined with a low-sugar diet on the management of non-alcoholic fatty liver disease: a randomized controlled trial. Nutrition. 2023;105:111847. Article CAS PubMed Google Scholar Wilkinson MJ, Manoogian ENC, Zadourian A, Lo H, Fakhouri S, ...
Loss of pancreatic insulin-secreting β-cells due to metabolic or autoimmune damage leads to the development of diabetes. The discovery that α-cells can be efficiently reprogrammed into insulin-secreting cells in mice and humans has opened promising ave
This study aimed to examine how p53 orchestrates autophagy and apoptosis to affect hepatosteatosis.MethodsHepG2 cells were treated with oleic acid (OA) for 24 h to induce hepatosteatosis. Mice were fed a high-fat diet for 20 or 40 weeks to induce hepatosteatosis.ResultsOA induced a dose-...
Patients with incomplete dataor with cirrhosis due to a congenital abnormality suchas primary biliary cirrhosis were excluded; thus, a totalof 3857 patients were enrolled in the present study.The eGFR, which was calculated by using either the modification of diet in renal disease (MDRD) equation...
Thus, the BHB-mediated pathway acting in concert with other therapeutic modalities will potentially become an exemplar of “metabolic therapy.“ 97 Moreover, research indicates that a high-fat diet (HFD) increases TC uptake of fat, alters fatty acid distribution in the tumor microenvironment (...
摘要: Acta Diabetologica - To investigate the relationship between metabolic-associated fatty liver disease (MAFLD) and end-stage renal disease (ESRD) in patients with biopsy-confirmed diabetic...关键词: Type 2 diabetes mellitus Metabolic-associated fatty liver disease Diabetic nephropathy ...
While humans can produce choline in the liver, the amount your body can naturally synthesize is not sufficient. This compound must be obtained from your diet.[v] Unfortunately, according to theInstitute of Medicine, only 10% of Americans are consuming an “adequate” amount of choline. Here’...
2 Program of Agriculture Science, National Chiayi University, Chiayi 600355, Taiwan 3 Department of Microbiology, Immunology and Biopharmaceuticals, National Chiayi University, Chiayi 600355, Taiwan 4 Animal Industry Division, Livestock Research Institute, Council of Agriculture, Tainan 712009, Taiwan ...