Neotron Pharma provides Stability tests according to ICH standards (zones I, II, IV). We can carry out stability studies in their entirety (storage + analysis) or provide only storage service. The conditions we can offer are listed below: ...
Conditions for Forced Degradation Studies: 1. Hydrolytic Degradation:Hydrolysis is a common degradation process by the reaction of chemical with water at different pH values. In forced degradation, the drug reacted with the water at acidic and basic conditions. The concentration of the acid or base...
Explain the benefits of using liver S9 fraction for drug metabolism studies. The liver is the main organ of drug metabolism in the body. Subcellular fractions are usefulin vitromodels of hepatic clearance as they contain many of the drug metabolizing enzymes found in the liver. The two main su...
Explain the benefits of using liver microsomes for drug metabolism studies? The liver is the main organ of drug metabolism in the body. Subcellular fractions such as liver microsomes are useful in vitro models of hepatic clearance as they contain many of the drug metabolizing enzymes found in ...
V μL106cells= Incubation Volume (μL)Number of cells in incubation (x106) Intrinsic Clearance CLint (μL/min/million cells)= V x 0.693t1/2 What are the benefits of using hepatocytes for drug metabolism studies? The liver is the main organ of drug metabolism in the body. Hepatocytes...
Stability studiesA precise, accurate, economical and reproducible UV, RP-HPLC and UPLC method has been developed for the estimation of Prenoxdiazine hydrochloride in pharmaceutical and bulk dosage form. Each of the developed method has been validated for the analysis of Prenoxdiazine hydrochloride.#...
Stability studies represent considerable investment in cost and time. What steps can be taken to mitigate the risks of losing valuable samples in storage due to unforeseen disasters? Stability storage and stability studies play a fundamental part in the lifecycle of a pharmaceutical drug product. From...
EBSCO jocpr.com (全网免费下载) jocpr.com (全网免费下载) pharmanest.net (全网免费下载) 相似文献 参考文献 引证文献A validated RP- HPLC method for the analysis of Moxifloxacin Hydrochloride in pharmaceutical dosage forms and stability studies MV Priya,P Madhavan,P Kumar - Journal of Chemical and...
Recently, significant focus has been placed on the development of suitable stability-indicating studies in pharmaceutical analysis. A comprehensive eco-friendly stability-indicating RP-HPLC method has been developed and validated for the determination of piracetam and vincamine in hard gelatin capsule dosage...
Although numerous studies have addressed the oxidation of PS20 and PS80, a systematic and PS concentration-dependent comparison between both polysorbates under pharmaceutically relevant conditions (5 °C without oxidation accelerators) is currently missing in the literature [60]. Here, we investigated ...