During simulation, the nanoparticle is closed to DNA and phosphate groups direct the particles into the major grooves of the DNA molecule. Because of peeling and untwisting states that are occur at end of DNA, the nucleotide base lies flat on the surface of GNP. The configuration entropy is ...
What aspects of DNA's structure contribute to the stability of the DNA molecule? DNA: DNA is an organic biomolecule that is acidic by nature. It has a nucleotide sequence that determines the structure and functions of an organism. It is coiled to form chromosomes. Answer and...
The specific values of pKafi and pKaui depend on the internal and external factors. The former reflects the sequence and structure of the DNA molecule and the position of specific cytosines, while the latter reflect temperature, pressure, and solvent composition, including the presence of co...
Transcription-repressing proteins most commonly act by blocking RNAP access to the promoter (Fig. 1a). A library of homologues of the DNA binding protein TetR and their cognate operator sequences was built by Stantonet al., and it contains 16 orthogonal variants sourced from sequence databases[...
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Mechanically stable specific heterodimerization between small protein domains have a wide scope of applications, from using as a molecular anchorage in single-molecule force spectroscopy studies of protein mechanics, to serving as force-bearing protein l
Intuitively, the key phenotype must be related to mechanisms that determine the interaction of the extra-chromosomal DNA molecules with functional nuclear compartments, specifically sites of RNA and DNA synthesis. As DNA synthesis occurs during only part of the cell cycle it is likely that key ...
A “recombinant DNA molecule” is a DNA molecule that has undergone a molecular biological manipulation. A DNA “coding sequence” is a double-stranded DNA sequence which is transcribed and translated into a polypeptide in a cell in vitro or in vivo when placed under the control of ...
17 The conformation transition results in soluble random coil SF molecules folding into a stable β-sheet conformation to form water-insoluble molecule networks, in which the remaining random coil regions and other soluble protein fragments are embedded.12 When the amount of β-sheet exceeds a ...
Recently developed DNA-based analogues of membrane proteins have advanced synthetic biology. A fundamental question is how hydrophilic nanostructures reside in the hydrophobic environment of the membrane. Here, we use multiscale molecular dynamics (MD) simulations to explore the structure, stability and ...