目的探讨长链非编码RNAST7-AS1对卵巢癌细胞增殖、迁移及侵袭能力的影响及与其与miR-580-3p的调控机制。方法选取2019年6月至2021年6月绍兴市人民医院30例卵巢癌患者手术切除的上皮性卵巢癌(EOC)组织及配对的癌旁正常组织。采用荧光实时定量PCR(RT-qPCR)检测EOC及癌旁正常组织ST7-AS1表达水平;小干扰RNA(siRNA)转染...
ST7-AS1Lung adenocarcinomaEpithelial-mesenchymal transitionmiR-181b-5pKPNA4Background Growing evidence suggests that suppressor of tumorigenicity 7 antisense RNA 1 (ST7-AS1) is an oncogenic long noncoding RNA (lncRNA). However, little is known on its clinical significance, biological functions, or ...
凋亡目的探究微小RNA-27b-3p(miR-27b-3p)通过调控长链非编码RNA ST7-AS1(lncRNA ST7-AS1)对非小细胞肺癌(NSCLC)细胞增殖,凋亡和侵袭的影响.方法通过qRT-PCR分析miR-27b和lncRNA ST7-AS1在人正常肺上皮BEAS-2B细胞和人NSCLC细胞系(A549,H358,H1299及NCL-H2073)中的表达情况.通过生物信息学和双荧光素酶...
Overall, overexpression of ST7-AS1 enhances apoptosis and represses proliferation of PTC cells via targeting the miR-181b-5p/TRIM3 axis, which may help broaden the horizon and establish the foundation to develop therapeutic strategies for PTC in the future....
目的探讨长链非编码RNA ST7-AS1对卵巢癌细胞增殖,迁移及侵袭能力的影响及与其与miR-580-3p的调控机制.方法选取2019年6月至2021年6月绍兴市人民医院30例卵巢癌患者手术切除的上皮性卵巢癌(EOC)组织及配对的癌旁正常组织.采用荧光实时定量PCR(RT-qPCR)检测EOC及癌旁正常组织ST7-AS1表达水平;小干扰RNA(siRNA)转染...
Long non-coding RNA ST7-AS1PTBP1Positive feedback loopp53Glioma is the most prevalent intracranial tumour, with considerable morbidity. Long non-coding RNAs are important in the biological processes of various cancers. However, little is known about ST7 antisense RNA 1 (ST7-AS1) and its role...
MK increased the DDP resistance and upregulated the expression of ST7-AS1 in DDP-resistant GC cells. Additionally, ST7-AS1 knockdown increased the sensitivity to DDP by inhibiting EMT. Moreover, ST7-AS1 knockdown significantly decreased the phosphorylation of PI3K and AKT, and suppressed EMT, ...
GENE expressionCERVICAL cancerCANCER invasivenessPI3K/AKT pathwayThe image from Figure 5D, C-33A, si-ST7-AS1 miR-543 inhibitor, has been duplicated with the image from Figure 4F, U2OS, si-NC, from Zhao X, Li J, Yu D. MicroRNA-939-5p directly targets IGF-1R to inhibit the aggressive ...