MUC1 goes through the process of autocleavage at a SEA (sperm protein, enterokinase and agrin) domain, and splits into MUC1 N-terminal (MUC1-N) and C-terminal (MUC1- C) subunits, which in turn form a non-covalent heterodimer [27, 28]. MUC1-N as a physical barrier protects normal...
2F-G). The embryonic kidneys in the Hs3st3a1:Hs3st3b1 double knockout form variable double ureters, however this phenotype was observed with a low penetrance [28]. We conclude that generation of knockout mice where multiple Hs3st isoforms are deleted may present with abnormal developmental ...