Hyperforin is a polyprenylated acylphloroglucinol derivative from Hypericum perforatum (St. John's wort). It exhibits antidepressant activity by a novel mechanism of action, antibiotic activity against gram-positive bacteria, and antitumoral activity in vivo. However, it also produces drug-drug ...
St. John's wort (SJW) extract, a herbal medicine with antidepressant effects, is a potent inducer of intestinal and/or hepatic cytochrome P450 (CYP) enzymes and P‐glycoprotein (P‐gp), which can cause clinically relevant drug interactions. It is currently not known whether SJW...
B. The production of hypericins and hyperforin by in vitro cultures of St. John's wort (Hypericum perforatum). Biotechnol. Appl. Biochem. 39:71-81; 2004.Kirakosyan A, Sirvent T M, Gibson D M, et al. The production of hypericins and hyperforin by in vitro cultures of St. John's ...
cells.MethodsThe effect of compounds from St John's wort extract on the downregulation of β1-adrenergic receptor-GFP fusion proteins (β1AR-green fluorescent protein (GFP)) of transfected rat C6 gliobastoma cells (C6-β1AR-GFP) was investigated by means of confocal laser scanning microscopy ...
John's wort is widely used as an anti-depressant and anti-inflammatory remedy in traditional andherbal medicine. Based on St. John's wort properties, the therapeutic potentials of an H. perforatum extract (HPE) and a single component,hyperforin were evaluated for effectiveness against MOG35-55-...
St. John’s wortHyperforinThe extract of Hypericum perforatum (St. John's wort, SJW) and its component hyperforin (HPF) were previously shown to inhibit cytokine-induced activation of signal transducer and activator of transcription-1 and nuclear factor κB and prevent apoptosis in a cultured β...
Brown, Donald
The St. John's wort preparations studied exhibited large differences in hypericin and hyperforin content and are not interchangeable for the treatment of mild-to-moderate depression. Pharmacists should take this variability into account when counseling patients on the use of St. John's wort products...
Verotta, LuisellaAppendino, GiovanniJakupovic, JasminBombardelli, EzioVerotta L, Appendino G, Jakupovic J & Bombardelli E (2000) Hyperforin analogs from St. John’s wort ( Hypericum perforatum ). J. Nat. Prod. 63: 412–415.
Hyperforin in St. John’s wort drug interactions[J] . Rajanikanth Madabushi,Bruno Frank,Bernd Drewelow,Hartmut Derendorf,Veronika Butterweck.European Journal of Clinical Pharmacology . 2006 (3)Madabushi R, Frank B, Drewelow B, et al. Hyperforin in St John’s wort drug interactions. Eur ...