目的探讨长链非编码RNA SSTR5反义RNA 1(SSTR5-AS1)对喉癌细胞侵袭迁移和磷脂酰肌醇3激酶(PI3K)/蛋白激酶B(Akt)通路的影响.方法采用实时定量PCR(q PCR)检测人鼻咽上皮细胞NP69和喉癌细胞(TU-212,TU-177和Hep-2)的SSTR5-AS1水平.构建SSTR5-AS1高表达质粒pc DNA3.1-SSTR5-AS1并采用脂质体转染Hep-2细胞(过...
Knockdown of SSTR5-AS1 sensitized drug resistant GBC cells to gemcitabine in vitro and strongly inhibited xenografts formed by drug resistant GBC cells in vivo. Moreover, we found via streptavidin pull down assay that NONO specifically binds to sense sequence of SSTR5-AS1 and prevented proteasome ...
SSTR5-AS1 silencing attenuated the malignant behavior of ESCA cells through the ITGB6-mediated JAK1/STAT3 axis. Conclusion: SSTR5-AS1 promotes tumorigenesis of ESCA by interacting with EIF4A3 to regulate ITGB6/JAK1/STAT3 axis, which serves a basis for discovering strategies against ESCA. PLAIN ...
Diagnostic and prognostic significance of long noncoding RNA SSTR5-AS1 in patients with gastric cancerCHENG, Y.DI, J.WU, J.SHI, H.-T.ZOU, B.-C.ZHANG, Y.XIE, D.-H.European Review for Medical & Pharmacological Sciences
The level of methylation of the lncRNA genes HOTAIRM1 and SSTR5-AS1 is associated with indicators of breast cancer progression (stage of the tumor process, tumor size, presence of metastases in the lymph nodes). A model has been proposed for assessing the risk of developing lymphogenous ...