[摘要]背景与目的:免疫检查点抑制剂(immune checkpoint inhibitor,ICI)在过去10年深刻改变了抗肿瘤治疗的格局,显著延长了恶性肿瘤患者的生存期。但随着其在临床上的广泛使用,免疫治疗相关不良反应(immune-related adverse event,irAE)也逐渐...
sstII prevents growth factor-induced cell proliferation through activation of the tyrosine phosphatase SHP-1 leading to induction of the cyclin-dependent kinase inhibitor p27Kip1. Here, we investigate the signaling molecules linking sst2 to p27Kip1. In Chinese hamster ovary-DG-44 cells stably ...
Necrotic tissue was removed and extracted with RIPA buffer (50 mM Tris-HCl, pH 7.4, 150 mM NaCl, 1% NP-40, 0.5% deoxycholate, 0.1% sodium dodecyl sulfate and 2 mM EDTA) containing the cOmplete Protease Inhibitor Cocktail and PhosSTOP Phosphatase Inhibitor Cocktail (Roche Applied Science, Pe...
背景与目的:免疫检查点抑制剂(immune checkpoint inhibitor,ICI)在过去10年深刻改变了抗肿瘤治疗的格局,显著延长了恶性肿瘤患者的生存期.但随着其在临床上的广泛使用,免疫治疗相关不良反应(immune-related adverse event,irAE)也逐渐被报道和关注,但目前尚缺乏可靠的生物学指标用于预测irAE的发生风险.本文通过联合多个生物...
Objective: To investigate the value of soluble carcinogenic inhibitor 2(sST2), cardiac troponin I(cTnI), high-sensitivity C-reactive protein(hs-CRP) and N-... Z Chen,X Huang,M Zeng,... - 《Journal of Southeast University》 被引量: 0发表: 2019年 SERUM ST2 IS A STRONGER PROGNOSTIC MARK...
[500 mM KCl, 100 mM Tris-HCl, pH 8.3], distilled, autoclaved water, 1 mM dinucleotides, 2.5U/µL MuLV reverse transcriptase, 1U/µL RNase inhibitor, and 2.5 µM random hexamers) was added together with 200 ng RNA template. The total reaction volume of 20 µL was incubated at ...
By co-immunoprecipitation, we next found EX-527 (a Sirt1 selective inhibitor) treatment to reverse the effect of miR-199 on P300 acetylation (Fig. 7a–c). Moreover, while EX-527 did not have any impact on the effect of miR-199 on the interaction between Sirt1 and P300 under stretching...
Tumor necrosis factor α is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1 Obesity is associated with a cluster of abnormalities, including hypertension, insulin resistance, hyperinsulinemia, and elevated levels of both plasminoge... F Samad,KT Uysal,SM Wiesbrock...
免疫检查点抑制剂免疫相关不良反应生长刺激表达基因2蛋白预测模型背景与目的:免疫检查点抑制剂(immune checkpoint inhibitor,ICI)在过去10年深刻改变了抗肿瘤治疗的格局,显著延长了恶性肿瘤患者的生存期.但随着其在临床上的广泛使用,免疫治疗相关不良反应(immune-related adverse event,irAE)也逐渐被报道和关注,但目前尚...
Involvement of JAK2 inhibitor in the growth inhibition induced by the somastatin analogue, RC-160; Characterization of the signal transduction pathway responsible for the antimitogenic effect of RC-160.HortalaMarylisFerjouxGeraldineEstivalAgnesBertrand...