SSRI vs SNRI: Which is Better? Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) are both approved for the treatment of a wide range of health conditions. Doctors often prescribe a combination of the two for their patients’ treatment, oft...
SSRI和SNRI疗效相当,耐受性更好.pptx,SSRI和SNRI疗效相当,耐受性更好内部资料,仅供医学药学专业人士参考,严禁翻印及传播产品具体使用方法、不良反应、注意事项、禁忌症详见说明书抑郁症的发病机制和SSRI的药理机制中枢5-HT功能低下是抑郁症的主要病理机制中枢5-HT的代谢
1.SánchezC.Thepharmacologyofcitalopramenantiomers:theantagonismbyR-citalopramontheeffectofS-citalopram.BasicClinPharmacolToxicol.2006;99:91-95 2.Sanchez,Bræstrup.Escitalopram:auniquemechanismofaction.IntJPsychClinPract2004;8(suppl):11-33.Sánchezetal.Escitalopramversuscitalopram:thesurprisingroleoftheR-...
2项为艾司西酞普兰与文拉法辛比较;分析结果:艾司西酞普兰改善抑郁症患者睡眠症状的作用显著优于SNRI。 治疗第2周即出现显著性差异。 末次结果结转分析(LOCF)也显示出整体差异。艾司西酞普兰治疗期间出现的失眠不良反应也显著低于SNRI。 (6.5% vs 12.1%,p=0.0020)SteinDJ,LopezAG. Effectsofescitalopramonsleepproble...
1.SánchezC.Thepharmacologyofcitalopramenantiomers:theantagonismbyR-citalopramontheeffectofS-citalopram.BasicClinPharmacol Toxicol.2006;99:91-95 2.Sanchez,Bræstrup.Escitalopram:auniquemechanismofaction.IntJPsychClinPract2004;8(suppl):11-3 3.Sánchezetal.Escitalopramversuscitalopram:thesurprisingroleoftheR-...
In particular, a genome-wide association study of SSRI/SNRI-induced sexual dysfunction in a Japanese cohort identified 11 MDGA2 SNPs that were significantly associated with the outcome at a genome-wide significant level.44 Furthermore, MDGA2 was identified as a potential neuroticism-related gene in...
1.SánchezC.Thepharmacologyofcitalopramenantiomers:theantagonismbyR-citalopramontheeffectofS-citalopram.BasicClinPharmacolToxicol.2006;99:91-95 2.Sanchez,Bræstrup.Escitalopram:auniquemechanismofaction.IntJPsychClinPract2004;8(suppl):11-33.Sánchezetal.Escitalopramversuscitalopram:thesurprisingroleoftheR-...
Snchez C. The pharmacology of citalopram enantiomers: the antagonism by R-citalopram on the effect of S-citalopram. Basic Clin Pharmacol Toxicol. 2006;99:91-95Sanchez, Brstrup. Escitalopram: a unique mechanism of action. Int J Psych Clin Pract 2004;8(suppl):11-3Snchez e 4、t al. ...
1.SánchezC.Thepharmacologyofcitalopramenantiomers:theantagonismbyR-citalopramontheeffectofS-citalopram.BasicClinPharmacolToxicol.2006;99:91-95 2.Sanchez,Bræstrup.Escitalopram:auniquemechanismofaction.IntJPsychClinPract2004;8(suppl):11-33.Sánchezetal.Escitalopramversuscitalopram:thesurprisingroleoftheR-...
SSRI和SNRI疗效相当耐受性更好 2 •抑郁症的収病机制和SSRI的药理机制 3 中枢5-HT功能低下是抑郁症的主要病理机制 •中枢5-HT的代谢:5-HT转 运体重新吸收位于突触间隙 的5-HT,収挥再摄叏作用。 •正常人的5-HT神经递质与 叐体处于平衡状态。 •抑郁的収生与突触间隙的5- HT浓度降低有直接相关。