The fact that selective serotonin reuptake inhibitors (SSRIs) have antidepressant effects in some patients supports the notion that serotonin plays a role in the mode of action of antidepressant drugs. However, neither the way in which serotonin may alleviate depressed mood nor the reason why ...
30 Neuroprogenitor cell proliferation is an early event of neurogenesis, a process by which new neurons are continuously generated and incorporated into the nervous system. Recent research has suggested that hippocampal neurogenesis may have a key role in antidepressant action.31, 32 A recent genetic...
(SSRIs)areefectiveinmajordepression.However,therearetwo seriousproblemsinthepharmacologicaltreatmentofdepressionsuchassideefectsandadelayedonsetofactionof 2_6weeks【1】.Therefore,thedrugsdesignstrategiesfocusingonincorporatinga5-HT1Aantagonistpharmacophore intoaSS pharmacophorehavebeenproposedf2_181.Thisdual5一HTtA/...
Nevertheless, analysis of antidepressant response data using a mixed linear model approach to estimate the proportion of phenotypic variance explained by genome-wide single-nucleotide polymorphisms (SNPs, the GREML approach) implemented in the Genome-Wide Complex Trait Analysis package10 has demonstrated ...