MDM2 amplification and fusion gene ss18-ssx in a poorly differentiated synovial sarcoma: A rare but puzzling conjunctionAmplificationDiagnosisLiposarcomaMDM2Synovial sarcomaThe detection of specific alterations by genetic analyses has been included in the diagnostic criterions of the World Health Organization...
基因简称(symbol) SS18[HGNC][GeneCards][NCBI] 基因种类(locus group) protein-coding gene 同源简称(alias symbol) SYT 基因家族代码(gene_family_id) [HGNC][GenScript] omim代码 600192 entrez码 6760[Vega] ensembl基因码 ENSG00000141380[Ensembl] ...
参考文献 [1]Ali O, Isaac J, Lioyd J. The SSX gene family: characterization of 9 complete genes. Int J Cancer, 2002, 101(5):448-453. [2]Matthew J, John L. The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma. Cancer Cell, 2018, 33(...
ToexplorethevalueofSS18genetranslocationinthediagnosisofsynovial sarcomaandprovidemolecularbiologicalbasisfordifferentialdiagnosisof complexsynovialsarcomacases;toanalyzetherelationshipbetweenSS18 genetranslocationandclinicalpathologicalfactorsrelatedtosynovial sarcoma,tostudyitsvalueinthepathogenesisandprognosisofsynovial ...
这个基因,以及ssx2和ssx4家族成员,参与了t(x;18)(p11.2;q11.2)易位,其特征性见于所有滑膜肉瘤。这种易位导致18号染色体滑膜肉瘤易位基因与X号染色体SSX基因的融合。编码的杂交蛋白可能负责转化活性。这种基因的选择性剪接导致多种转录变异。在X染色体上发现了一个相关的假基因。The product of this gene belongs ...
Fig. The fluorescence in situ hybridization (FISH) images showing SS18 gene rearrangement in one synovial sarcoma and one fibrosarcoma, A: There were one pair of fusion signals and one pair of break-apart signals in 85% tumor cells; B: two pairs of fusion signals in every nucleus 2.3...
Gene Summary Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries...
3、Güre AO, Wei IJ, Old LJ, et al. The SSX gene family: characterization of 9 complete genes. Int J Cancer. 2002 Oct 10;101(5):448-53. 4、2021年软组织肿瘤诊断病理学 第3版 王坚,喻林,刘绮颖主译. 作者 高宇慧 住院医师 陕西省西安市红会医院病理科 ...
CDS-H12580-1 pDonR223-SS18 GateWay 2ug/0.5ml ￥800 现货 CDS-H12580-2 pMD18-T-SS18 TA克隆 2ug/0.5ml ￥800-1500 1-2周SS18 重组腺病毒 货号产品名称Method规格价格货期 CDS-H12580-11 rAd-SS18 重组过表达腺病毒 10^10 vg/支 ￥2500 3-5周 CDS-H12580-12 rAd-sh-SS18 重组干扰腺病毒...
Gene ID (NCBI) 6760 Alternative Names SSXT;SYT Application Notes: The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user. WB 1:500 - 1:2000 IHC 1:50 - 1:200