SOX9 is a member of the SRY-related HMG-box (SOX) gene family of transcription factors1. The high mobility group (HMG) box of the mammalian testis-determining factor SRY encodes for a DNA-binding domain which is conserved in all SOX proteins throughout the animal kingdom and binds to ...
ANOP3;lcc;MCOPS3;Sox-2;SRY (sex-determining region Y)-box 2;SRY-related HMG box 2;ysb Historical Background Thesex-determining region Y(SRY/Sry) gene, which is a mammalian male-specifying factor on the Y chromosome, was first defined in 1990. Since its discovery, more than 20 differen...
Stem cells have been discovered as key players in the genesis of different neoplasms including craniopharyngioma (CP), a rare tumour entity in the sellar region. Sox2 and Sox9 are well-known stem cell markers involved in pituitary development. In this st
英文名字 Sox-2 Antibody,Sox2,Sox 2,SRY-box containing gene 2,sex determining region Y box-2,SRY related HMG box 2,Transcription factor SOX 2 供应商 Biovision 产品货号 3889-100 产品报价 ￥已停产 产品说明书 点击查看 购买方式 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联...
One gene known to be downstream from Sry in this cascade is Sox9, which encodes a transcription factor related to Sry by the HMG box. Like Sry, mutations in Sox9 disrupt male development, but unlike Sry, the role of Sox9 is not limited to mammals. This review focuses on what is known ...
背景SOX14 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins...
The Sox4 gene contains two important functional regions, namely, the SRY-related high-mobility-group (HMG) domain near the EMT in cancer The EMT refers to the morphological process in which epithelial cells are transformed into mesenchymal cells through specific procedures; this process plays an ...
背景SOX13 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It ha...
SRY盒相关基因7(SRY related high mobility group box 7,SOX7)为SRY相关HMG盒转录因子的家族成员之一,参加调控细胞死亡和胚胎发育等。报道称 [ 1 , 2 ],SOX7可经过对Wnt/β连环蛋白路径,影响了口腔鳞癌、肝癌等肿瘤细胞的转移侵袭等,在恶性肿瘤发病与进展中发挥了重要作用。在较多恶性肿瘤中SOX7 mRNA表达降低 ...
Lundberg Y, Ritzen M, Harlin J, Wedell A: Novel missense mutation (P131R) in the HMG box of SRY in XY sex reversal. Hum Mutat 1998, 11 (Suppl 1) : S328-S329.Lundberg Y, Ritze´n M, Harlin J, Wedell A. 1997. Novel Missense mutation (P131R) in the HMG box of SRY in ...