题目:致癌基因lncRNA ZNF561-AS1通过调节miR-26a-3p / miR-128-5p-SRSF6轴对大肠癌的增殖和存活至关重要。 Oncogenic lncRNA ZNF561-AS1 is essential for colorectal cancer proliferation and survival through regulation of miR-26a-3p/miR-128-5p-SRSF6 axis. ...
offers a therapy target for colorectal cancer[J]. Gut, 2017:gutjnl-2017-314983. 联系我们 地址:武汉市东湖高新技术开发区高新大道666 号光谷生物城C1 栋2 层 电话:027-65527552 网站:.seqhealth 邮箱:seqhealth@seqhealth
We identify 139 SRSF6-target genes in skin and show that this SR-rich protein binds to alternative exons in the pre-mRNA of the extracellular-matrix protein tenascin C, thus promoting the expression of isoforms characteristic of invasive and metastatic cancer independently of cell type. SRSF6 ...
Oncogenic lncRNA ZNF561-AS1 is essential for colorectal cancer proliferation and survival through regulation of miR-26a-3p/miR-128-5p-SRSF6 axis. Journal of Experimental & Clinical Cancer Research (IF=7.068) Published ...
Spliceosome is one of the most complex molecular machinery of the cell. At present, models of splicing are mainly delineated by detailed biochemical studies using yeast or a small number of model introns [30]. Considering the close relationship between AS and diseases including cancer, in vivo mo...
SCI文献精读题目:致癌基因lncRNA ZNF561-AS1通过调节miR-26a-3p / miR-128-5p-SRSF6轴对大肠癌的增殖和存活至关重要。 Oncogenic lncRNA ZNF561-AS1 is essential for colorectal cancer proliferation and survival through regulation of miR-26a-3p/miR-128-5p-SRSF6 axis. ...
Roles and mechanisms of alternative splicing in cancer - implications for care Nat. Rev. Clin. Oncol., 17 (2020), pp. 457-474 CrossrefView in ScopusGoogle Scholar Bourgeois et al., 2004 C.F. Bourgeois, F. Lejeune, J. Stévenin Broad specificity of SR (serine/arginine) proteins in the...
总之,茚达特罗被重新定位为通过靶向SRSF6来调节AS从而抑制CRC进展的新型治疗剂。 原文:Wan L, Yu W, Shen E, et al. SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer[J]. Gut, 2017: gutjnl-2017-314983....
ZO-1的异常剪接促进体外迁移和侵袭 SRSF6通过调节体内ZO-1选择性剪接促进肿瘤进展 indacaterol作为SRSF6的药理学抑制剂阻断了CRC进展 来源:SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer.Gut...
Protein splicingDe novo and acquired resistance, which are mainly mediated by genetic alterations, are barriers to effective routine chemotherapy. However, the mechanisms underlying gastric cancer (GC) resistance to chemotherapy are still unclear. We showed that the long noncoding RNA CRNDE was related...