Here we report in mice that lamin-A/C-deficient (Lmna−/−) and LmnaN195K/N195K mutant cells have impaired nuclear translocation and downstream signalling of the mechanosensitive transcription factor megakaryoblastic leukaemia 1 (MKL1), a myocardin family member that is pivotal in cardiac ...
SRF is a ubiquitous transcription factor that was first identified as a regulator of growth-factor regulated immediate-early genes. Working in partnership with its coactivators MRTF-A and MRTF-B, SRF regulates the majority of cytoskeletal genes7,8, including many that are involved in fibrosis9,10...