Irisin胆固醇SREBP2HMGCR目的:随着肥胖人群在全球范围内的不断扩大,代谢相关性脂肪肝病(metabolic associated fatty liver disease,MAFLD)的发病率也在逐年升高.MAFLD是一种多因素导致的慢性肝病,是代谢综合征在肝脏的表现,而肝脏内胆固醇代谢紊乱是MAFLD发生与发展的重要机制之一.减重代谢手术可以有效减轻肥胖患者体重并...
结果在ACS患者单核-巨噬细胞内,各干预组SREBP-2和HMGCR mRNA相对表达量较对照组增加(P0.05),各干预组内SREBP-2和HMGCR mRNA表达的量也有显著性差异(P0.05).结论Ox-LDL能显著促进ACS患者单核-巨噬细胞内SREBP-2和HMGCR mRNA的表达增加,并且在一定范围内,随着ox-LDL浓度的增加,SREBP-2和HMGCR mRNA的表达量也...
目的 观察复方片仔癀肝宝对慢性酒精性肝损伤大鼠肝脏SREBP2-HMGCRa表达的影响,探讨其调节肝脏胆固醇合成通路的机制.方法 将60只SD雄性大鼠随机平均分为正常组,模型组,对照组,复方片仔癀肝宝低,中,高剂量组6个组,采用梯度增加酒精浓度灌胃制备大鼠慢性酒精性肝损伤模型,同时分别灌服对照药水飞蓟宾葡甲胺片(0.03 g·kg...
Conclusion Transthyretin regulated cholesterol metabolism mainly through inhibiting LXR伪-CYP7A1 and promoting SREBP2-HMGCR. And linc00657 could negatively regulate Transthyretin by inhibiting miR-205-5p, providing novel therapeutic targets for decreasing serum cholesterol level. Besides, Transthyretin could ...
ox-ldl对急性冠脉综合症患者外周血单核-巨噬细胞srebp-2和hmgcrmrna表达的影响 全部标题作者 关键词摘要 OALib Journal期刊 ISSN: 2333-9721 费用:99美元 投递稿件 查看量下载量 510 更多... 南方医科大学学报2009 张培东刘映峰郭阳缪绯余志国王世祥 Full-TextCite this paperAdd to My Lib...
目的 探讨高脂诱导IR apoE-/-小鼠胆固醇代谢基因的变化.方法 健康雄性apoE-/-小鼠,随机分为普食组(NF组)和高脂喂养组(HF组),共喂养16周.采用实时荧光定量PCR测定肝组织羟甲基戊二酸单酰辅酶A还原酶(HMGCR),固醇调节元件结合蛋白-2(SREBP-2),低密度脂蛋白受体(LDLr)基因mRNA表达.结果 HF组小鼠FBG,Fins,TC,...
Our previous study found that thyroid-stimulating hormone promoted sterol regulatory element-binding protein-2 (SREBP-2) expression and suppressed AMP-activated protein kinase (AMPK) activity in the liver, but it was unclear whether there was a direct link between TSH, AMPK and SREBP-2. Here, ...
目的:观察益气养阴消癥通络中药及其拆方对糖尿病性脂肪肝(Diabetic Fatty Liver,DFL)大鼠肝组织固醇调节元件结合蛋白2(Sterol regulatory element binding proteins 2,SREBP2)和羟甲基戊二酸单酰辅酶A还原酶(hydroxymethyl glutaryl coenzyme A reductase,HMGCR)及脂肪变性的影响,研究其治疗作用,并探讨其可能机制.方法:55...
(HMGCR),固醇调节元件结合蛋白-2(SREBP-2),低密度脂蛋白受体(LDLr)基因mRNA表达.结果 HF组小鼠FBG,FIns,TC,TG,HDL-C,LDL-C和FFA水平均明显升高(P均〈0.01).HF组小鼠肝脏HMGCR,SREBP-2和LDLr mRNA表达水平均明显降低(P〈0.01或P〈0.05).结论在高脂喂养apoE-/-小鼠,HMGCR,SREBP-2和LDLr的变化在其胆固醇...
SREBP-2PI3K/AktAims: Disruption of cholesterol homeostasis has been identified as a major factor in the pathogenesis of atherosclerosis, myocardial infarction, and strokes. Long noncoding RNAs (lncRNAs) have emerged as critical players in cellular cholesterol metabolism, but their functions are still ...