Pancreatic cancer, High glucose, SREBP1, AutophagyBackgroundDiabetes is recognized to be a risk factor of pancreatic cancer, but the mechanism has not been fully elucidated. Sterol regulatory element binding protein 1 (SREBP1) is an important transcription factor involved in both lipid metabolism ...
unfolded protein response (UPR), leading to ER stress-induced apoptosis and autophagy [35]. Silencing of SREBP-1 attenuates this stress response [35], whereas SREBP-1 upregulation by high glucose promotes cell growth and inhibits apoptosis and autophagy in pancreatic cancer cells [36]. Furthermor...
SREBP1 regulates tumorigenesis and prognosis of pancreatic cancer through targeting lipid metabolism. Tumour Biol. 36, 4133–4141 (2015). CAS PubMed Google Scholar Brown, M. S. & Goldstein, J. L. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound ...
Sterol regulatory element-binding protein 1 inhibitors decrease pancreatic cancer cell viability and proliferation. Biochem Biophys Res Commun. 2017;488(1):136–40. Article PubMed Google Scholar Zhang J, et al. EGFR modulates monounsaturated fatty acid synthesis through phosphorylation of SCD1 in ...
Patients with EGFR mutations in non-small cell lung cancer (NSCLC) have been greatly benefited from gefitinib, however, the therapeutic has failed due to the presence of acquired resistance. In this study, we show that gefitinib significantly induces downregulation of Sterol Regulator Element Binding...
Additionally, the apoptotic potential of Silibinin in pancreatic cancer SW1990 cells supported by the activation of JNK/SAPK dependent increase in pro-apoptotic proteins, ROS generation, cytochrome c release, Atg5 and Beclin-1 proteins, has also been documented recently by a group of authors [52]...
Cancer cells display distinctive metabolic changes to support their rapid accumulation of biomass, otherwise known as metabolic reprogramming.1,2 A range of processes are altered, including nutrient intake, membrane biosynthesis, energy storage and production, and generation of signaling intermediates. The...
CancerPancreatic cancer (PC) is a lethal disease and associated with metabolism dysregulation. Nogo-B is related to multiple metabolic related diseases and types of cancers. However, the role of Nogo-B in PC remains unknown. In vitro , we showed that cell viability and migration was largely ...
Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 2009; 9: 537–549. Article CAS PubMed Google Scholar Luedde T, Beraza N, Kotsikoris V, van Loo G, Nenci A, De Vos R et al. Deletion of NEMO/IKKgamma in liver parenchymal cells causes ...
[11,12]. ENPP2 has been described to be engaged in several solid neoplasms, such as chondrosarcoma [13], breast cancer [14], hepatocellular carcinoma [15], and pancreatic cancer [16], and has been mentioned in multiple myeloma [17]. Nevertheless, the effects of ENPP2 inhibition in CLL ...