Metabolism must be tightly regulated to fulfil the dynamic requirements of cancer cells during proliferation, migration, stemness and differentiation. Src is a node of several signals involved in many of these biological processes, and it is also an impo
SRC mediates a wide range of signaling pathways that play a pivotal role in normal cellular processes, including proliferation, adhesion, angiogenesis, and migration (Fig.3). Given the contribution of these features to some of the “hallmarks of cancer,” it is unsurprising that aberrant activatio...
Activation of Src through Csk Down-Regulation Enhances Proliferation and Angiogenesis in Pancreatic Cancer: 180Pema, MehulKunte, DhanajayRamesh, WaliJennifer, KoetsierRoy, HemantOfficial journal of the American College of Gastroenterology | ACG
Triple-Negative Breast Cancer (TNBC) is the most aggressive type of breast malignancy, with chemotherapy as the only mainstay treatment. TNBC patients have the worst prognoses as a large fraction of them do not achieve complete pathological response post
Exploitation of FAK activity in human tumors occurs through elevated expression, a situation that correlates with increased cancer cell motility, invasiveness, and proliferation Owens et al. 1995, Parsons 2003. FAK and c-Src have been shown to form a transient, active complex following integrin ...
Gastric cancer (GC) is one of the most common cancers causing a poor prognosis worldwide. HOXA13, as a member of the homeobox (HOX) family, is involved in the regulation of cancer progression and has attracted increasing attention, as a potential novel t
Full catalytic activity of Src requires phosphorylation of tyrosine 418. The tyrosine 529 is located near the carboxyl terminus of Src and acts as a negative regulator, in that Src is held in the inactive form through an intramolecular interaction between the SH2 domain and the carboxyl terminus...
KAI1 was initially identified as a metastasis-suppressor gene in prostate cancer. It is a member of the tetraspan transmembrane superfamily (TM4SF) of membrane glycoproteins. As part of a tetraspanin-enriched microdomain (TEM), KAI1 inhibits tumor metast
Full size image Arp2/3 complexes have been reported to affect spindle migration, asymmetric division, and cytokinesis during oocyte meiosis by regulating actin cap formation [23,24,25]. Accordingly, NLRP4E KD decreased the Arp3 intensity in the actin cap region during chromosome translocation (Fig...
EPS8 is a scaffolding protein that regulates proliferation, actin dynamics and receptor trafficking. Its expression is increased in cancer, enhancing mitogenesis, migration and tumorigenesis. Src phosphorylates EPS8 at four tyrosine residues, although th