Pallen CJ.Protein tyrosine phosphatase alpha (PTPalpha): a Src family kinase activator and mediator of multiple biological effects. Current Topics in Medicinal Chemistry . 2003Pallen C J.Protein tyrosine phosphatase alpha(PTPalpha):a Src family kinase activator and mediator of multiple biological ...
Physiological regulators of Src were also promptly detected in mitochondria, including CSK [112], SHP-2 [114, 115] and PTP1B [115, 116], and even a new activator of Src was discovered, PTPD1 [117] (Fig. 4). Reported Src substrates in the mitochondria include, most notably, several ...
Human ES cells express multiple Src-family kinases Despite the expression of eleven Src-related kinases in thehuman genome, only c-Yes has been studied in the context of hES cell biology (Anneren, 2008). While the c-Yes protein is expressed in both pluripotent hES cells and differentiated EB...
Protein Tyrosine Phosphatase (PTP): A Src Family Kinase Activator and Mediator of Multiple Biological Effects Pallen CJ: Protein tyrosine phosphatase alpha (PTPalpha): a Src family kinase activator and mediator of multiple biological effects. Curr Top Med Chem ... Pallen,C.J - 《Current Topics...
2.1Src 激酶与 Janus 激酶(Janus kinase)- 信号转导和转录激活因子(signal transducer and activator oftranscription,STAT)通路 STAT 可与特定的含磷酸化酪氨酸的肽段结合,能被多种细胞因子以及其他因子所激活。通常情况下,细胞因子受体亚基和 JAK 聚合,诱导 JAK 自磷酸化或反磷酸化以及随后的受体磷酸化,使 SH2 ...
5、应sds-pagesodium dodecyl sulfonate-polyacrylate gel electrophoresis十二烷基硫酸钠聚丙 烯酰胺凝胶电泳sfkssre-family tyrosine kinasessrc家族酪氨酸激酶statsignal transducers and activator of transcription信号转导及转录活化 因子tgf 卩transforming growth factor-卩转化生长因子卩tnf-atumor necrosis factor alpha肿...
RanBP9-overexpressing cells were treated with or without the Src activator pYEEI and RanBP9-knockdown cells were treated with or without the Src inhibitor AZD0530. Left, Src tyrosine kinase assay. Right, western blot analysis of Src and Akt expression and phosphorylation. Western blot values of...
Src蛋白激酶在动脉粥样硬化发生_发展中的研究进展_张小杰
(Signal transducer and activator of transcription 3,STAT3)信号通路.STAT3参与多种肿瘤的增殖分化,免疫逃避,血管新生及侵袭等生物调控过程.STAT3一方面为活化的受体和非受体酪氨酸激酶传递信号,另一方面发挥转录因子的作用.活化的STAT3形成同源二聚体或异源二聚体,从细胞质直接进入到细胞核,与基质金属蛋白酶(Matrix ...
significance in Alzheimer's disease and other prionic ailments, the prion protein PrPC attenuates Ca2 + entry in neurons via store-operated Ca2 + channels by preventing Fyn activation and tyrosine phosphorylation of STIM1, the Ca2 + sensor located at the endoplasmic reticulum and activator of Or...